PMID: 8938587Oct 1, 1996Paper

11 beta-Hydroxysteroid dehydrogenase in the rat adrenal

Journal of Molecular Endocrinology
M ShimojoPaul M Stewart

Abstract

11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the interconversion of biologically active cortisol to inactive cortisone in man, and corticosterone to 11-dehydrocorticosterone in rodents. As such, this enzyme has been shown to confer aldosterone-selectivity on the mineralocorticoid receptor and to modulate cortisol/corticosterone access to the glucocorticoid receptor (GR). Two kinetically distinct isoforms of this enzyme have been characterized in both rodents and man; a low-affinity NADP(H)-dependent enzyme (11 beta-HSD1) which predominantly acts as an oxoreductase and, more recently, a high-affinity NAD-dependent uni-directional dehydrogenase (11 beta-HSD2). In this study we have analysed the expression of both 11 beta-HSD1 and 11 beta-HSD2 isoforms in rat adrenal cortex and medulla and have investigated their possible roles with respect to glucocorticoid-regulated enzymes mediating catecholamine biosynthesis in adrenal medullary chromaffin cells. Using a rat 11 beta-HSD1 probe and a recently cloned in-house mouse 11 beta-HSD2 cDNA probe, Northern blot analyses revealed expression of mRNA species encoding both 11 beta-HSD1 (1.4 kb) and 11 beta-HSD2 (1.9 kb) in the whole adrenal. Consistent with this, 11 beta-deh...Continue Reading

Citations

May 24, 2000·The Journal of Steroid Biochemistry and Molecular Biology·D G RomeroC E Gomez-Sanchez
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·O AinsahB A Khalid
May 14, 2011·Reproductive Sciences·Naseem M KhorramOmid Khorram
Nov 29, 2014·Bulletin of Experimental Biology and Medicine·O P CherkasovaN V Kuznetsova
Jul 6, 2016·Frontiers in Neuroscience·Gavin P Vinson
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·M L RickettsP M Stewart
Apr 6, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·G MazzocchiG G Nussdorfer
Feb 24, 2001·Journal of Hypertension·Y KomiyamaH Takahashi
Aug 24, 2019·Stress : the International Journal on the Biology of Stress·Jessica L HillMichelle T Foster
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·O AinsahB A Khalid
Mar 16, 2011·Clinical and Experimental Pharmacology & Physiology·Masamichi YoshikaHakuo Takahashi
Aug 20, 2019·Chemical Research in Toxicology·Xiuxiu ChenRen-Shan Ge
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