11-Deoxycortisol controls hydromineral balance in the most basal osmoregulating vertebrate, sea lamprey (Petromyzon marinus).

Scientific Reports
Ciaran A ShaughnessyStephen D McCormick

Abstract

It is unknown whether and how osmoregulation is controlled by corticosteroid signaling in the phylogenetically basal vertebrate group Agnatha, including lampreys and hagfishes. It is known that a truncated steroid biosynthetic pathway in lampreys produces two predominant circulating corticosteroids, 11-deoxycortisol (S) and 11-deoxycorticosterone (DOC). Furthermore, lampreys express only a single, ancestral corticosteroid receptor (CR). Whether S and/or DOC interact with the CR to control osmoregulation in lampreys is still unknown. We examined the role of the endogenous corticosteroids in vivo and ex vivo in sea lamprey (Petromyzon marinus) during the critical metamorphic period during which sea lamprey increase osmoregulatory capacity and acquire seawater (SW) tolerance. We demonstrate in vivo that increases in circulating [S] and gill CR abundance are associated with increases in osmoregulatory capacity during metamorphosis. We further show that in vivo and ex vivo treatment with S increases activity and expression of gill active ion transporters and improves SW tolerance, and that only S (and not DOC) has regulatory control over active ion transport in the gills. Lastly, we show that the lamprey CR expresses an ancestral, s...Continue Reading

References

Feb 1, 1995·General and Comparative Endocrinology·P A VeilletteJ L Specker
Jan 1, 1997·Annual Review of Medicine·F CadepondE E Baulieu
Jan 22, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·W S MarshallS D McCormick
Aug 10, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Graham R ScottPatricia M Schulte
Jan 13, 2006·General and Comparative Endocrinology·Tatsuya Sakamoto, Stephen D McCormick
Apr 8, 2006·Science·Jamie T BridghamJoseph W Thornton
Mar 4, 2008·The Journal of Experimental Biology·Patrick Reis-SantosJonathan M Wilson
Dec 9, 2009·Molecular and Cellular Endocrinology·Phuong BuiScott P Kelly
Feb 23, 2010·General and Comparative Endocrinology·Pia KiilerichSteffen S Madsen
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·David A CloseWeiming Li
Sep 15, 2010·Molecular and Cellular Endocrinology·Geeta N Eick, Joseph W Thornton
Oct 12, 2010·Molecular and Cellular Endocrinology·Jyotsna B PippalPeter J Fuller
May 30, 2012·Respiratory Physiology & Neurobiology·Helen ChasiotisScott P Kelly
Aug 3, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Michael E BakerStephanie R Kattoula
Oct 18, 2013·Integrated Blood Pressure Control·John W Funder
Jun 28, 2014·General and Comparative Endocrinology·Satbir RaiDavid A Close
Mar 24, 2016·The International Journal of Developmental Biology·Christian MukendiNatalya V Nikitina
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Nov 7, 2016·Molecular and Cellular Endocrinology·Dennis KolosovScott P Kelly
Aug 12, 2017·The Journal of Experimental Biology·Dennis KolosovScott P Kelly
May 16, 2019·The Journal of Experimental Biology·Dennis Kolosov, Scott P Kelly
Aug 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Peter J FullerBrian J Smith
Oct 17, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ciaran A Shaughnessy, Stephen D McCormick
Nov 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andre BaranyStephen D McCormick

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Citations

Mar 3, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Yoshinao KatsuMichael E Baker
Nov 14, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Ciaran A Shaughnessy, Jason P Breves
Mar 21, 2021·General and Comparative Endocrinology·Andre BaranyStephen D McCormick
Jun 5, 2021·The Journal of Experimental Biology·Ciaran A Shaughnessy, Stephen D McCormick
Jul 9, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ian A BouyoucosW Gary Anderson

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Datasets Mentioned

BETA
AAK20930

Software Mentioned

MEGA7
GraphPad Prism
GraphPad
MarvinSketch
ClustalW

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