111In-labeled galectin-3-targeting peptide as a SPECT agent for imaging breast tumors.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Senthil R Kumar, Susan L Deutscher

Abstract

Galectin-3 is a member of the galectin family of beta-galactoside-binding animal lectins. Galectin-3 is overexpressed in a wide range of neoplasms and is associated with tumor growth and metastases. Given this fact, radiolabeled galectin-3-targeting molecules may be useful for the noninvasive imaging of tumors expressing galectin-3, as well as for targeted radionuclide therapy. In this study, the tumor cell-targeting and SPECT properties of a galectin-3-avid peptide identified from bacteriophage display were evaluated in human breast carcinoma cells and in human breast tumor-bearing mice. The galectin-3-avid peptide G3-C12 (ANTPCGPYTHDCPVKR) was synthesized with a Gly-Ser-Gly (GSG) linker at the amino terminus. After conjugation with 1,4,7,10-tetra-azacyclododecane-N,N',N''N'''-tetraacetic acid (DOTA), the peptide was labeled with (111)In. The radiochemical purity and stability of the compound was assessed by high-performance liquid chromatography. MDA-MB-435 human breast carcinoma cells expressing galectin-3 were used to characterize the in vitro binding properties of the radiolabeled compound. SCID mice bearing MDA-MB-435 xenografts were used as an in vivo model for biodistribution and imaging studies with the (111)In-labeled...Continue Reading

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Citations

Aug 2, 2012·Clinical & Experimental Metastasis·Jessica R Newton-NorthupSusan L Deutscher
Jun 6, 2012·Bioconjugate Chemistry·Qian GengZhi-Rong Zhang
Dec 5, 2013·Chemical Reviews·Bethany Powell Gray, Kathlynn C Brown
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May 10, 2012·Journal of Biomedicine & Biotechnology·Lei JiangZhen Cheng
Sep 2, 2009·Nuclear Medicine and Biology·Jessica R Newton-NorthupSusan L Deutscher
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