11beta-hydroxysteroid dehydrogenase type 2 in zebra finch brain and peripheral tissues

General and Comparative Endocrinology
Amnon KatzBarney A Schlinger

Abstract

The enzyme 11betaHSD2 inactivates glucocorticoids by synthesizing metabolites that bind poorly to mineralocorticoid and glucocorticoid receptors. Oscine songbirds (Passeriformes) are important models for investigating stress hormone effects on brain and behavior but nothing is known about 11betaHSD2 activity in the songbird brain. We measured 11betaHSD2 mRNA expression and enzymatic activity in brain of adult and developing male and female zebra finches. Since 11betaHSD2 plays an important role in GC metabolism in some peripheral organs we measured mRNA and catalytic activity also in the adult liver, kidney colon and gonads. 11betaHSD2 mRNA was detected in all brain regions examined with expression in the cerebellum and hypothalamus greater in females than in males; expression in ovaries was greater than in testes. No differences were detected in the other peripheral tissues. Catalytic activity of 11betaHSD2 could be measured in brain, but at low levels and no sex differences were measured in any region tested. Because 11betaHSD2 protects mineralocorticoid sensitive tissues from inappropriate CORT action, we also measured mineralocorticoid receptor (MR) expression in adult brain kidney and liver. MR mRNA was detected in all tis...Continue Reading

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Jul 30, 2008·The European Journal of Neuroscience·Amnon KatzBarney A Schlinger

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Citations

Jan 22, 2013·General and Comparative Endocrinology·Sophie RettenbacherMichael Lepschy
Mar 30, 2018·Frontiers in Endocrinology·Michelle A RenselBarney A Schlinger
Feb 7, 2021·General and Comparative Endocrinology·Michelle A Rensel, Barney A Schlinger

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