11Beta-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17beta-hydroxysteroid dehydrogenase-type 2

Biochemical and Biophysical Research Communications
Michael E Baker

Abstract

11Beta-hydroxysteroid dehydrogenase-type 2 (11beta-HSD2) regulates the local concentration of cortisol that can activate the glucocorticoid receptor and mineralocorticoid receptor, as well as the concentration of 11-keto-testosterone, the active androgen in fish. Similarly, 17beta-HSD2 regulates the levels of testosterone and estradiol that activate the androgen receptor and estrogen receptor, respectively. Interestingly, although human 11beta-HSD2 and 17beta-HSD2 act at different positions on different steroids, these enzymes are paralogs. Despite the physiological importance of 11beta-HSD2 and 17beta-HSD2, details of their origins and divergence from a common ancestor are not known. An opportunity to understand their evolution is presented by the recent sequencing of genomes from sea urchin, a basal deuterostome, and amphioxus, a basal chordate, and the availability of substantial sequence for acorn worm and elephant shark, which together provide a more complete dataset for analysis of the origins of 11beta-HSD2 and 17beta-HSD2. BLAST searches find an ancestral sequence of 17beta-HSD2 in sea urchin, acorn worm and amphioxus, while an ancestral sequence of 11beta-HSD2 first appears in sharks. Sequence analyses indicate that 17...Continue Reading

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Citations

Aug 23, 2011·Genome Biology and Evolution·Ricard AlbalatMichael Schubert
Jan 23, 2014·Molecular and Cellular Endocrinology·Carlos F LagosCarlos E Fardella
Nov 9, 2011·Molecular and Cellular Endocrinology·Janina TokarzJerzy Adamski
Aug 3, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Michael E BakerStephanie R Kattoula
Aug 1, 2013·Physiological Reviews·Karen ChapmanJonathan Seckl
Feb 20, 2021·Molecular and Cellular Endocrinology·Elise P Gomez-Sanchez, Celso E Gomez-Sanchez

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