11C-acetate positron emission tomography imaging and image fusion with computed tomography and magnetic resonance imaging in patients with recurrent prostate cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Stefan WachterKurt Kletter

Abstract

To assess the clinical value of computed tomography (CT) and magnetic resonance imaging (MRI) image fusion with 11C-acetate (AC) positron emission tomography (PET) imaging for detection and exact location of clinically occult recurrences. Fifty prostate cancer patients with elevated/increasing serum prostate-specific antigen levels after radical therapy underwent whole-body AC PET. Uptake was initially interpreted as normal, abnormal, or equivocal. In case of abnormal or equivocal uptake, additional conventional imaging techniques, such as CT, MRI, and bone scans, were performed. To precisely define the anatomic location of abnormal uptake and to improve characterization of equivocal lesions, a software-assisted image fusion (CT-PET, MRI-PET) was performed and evaluated as site-by-site analysis of 51 abnormal (n = 37) or equivocal (n = 14) sites of all 50 patients. In 17 patients, additional histopathologic evaluation was available. In five (10%), 13 (26%), and 32 (64%) of the 50 patients, AC PET studies demonstrated AC uptake judged as normal, equivocal, and abnormal, respectively. Image fusion changed characterization of equivocal lesions as normal in five (10%) of 51 sites and abnormal in nine (18%) of 51 sites. It precisely...Continue Reading

References

Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Nov 1, 1994·The Journal of Urology·A W Partin, J E Oesterling
Aug 1, 1996·Nuclear Medicine and Biology·S D YehH I Scher
Jan 30, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·P D ShreveR L Wahl
Mar 18, 2000·Japanese Journal of Clinical Oncology·N OyamaK Okada
Jun 30, 2001·Seminars in Nuclear Medicine·O IsraelA Frenkel
Sep 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Jörg KotzerkeSven N Reske
Feb 18, 2003·European Journal of Nuclear Medicine and Molecular Imaging·E FrickeA R Boerner
Sep 10, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Heiko SchöderHenry W D Yeung
Sep 25, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Markus MitterhauserKurt Kletter

❮ Previous
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Citations

Sep 29, 2006·Der Urologe. Ausg. A·S N ReskeG Glatting
Oct 13, 2007·Der Urologe. Ausg. A·S N Reske
Sep 11, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Sven N ReskeGerhard Glatting
Sep 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·B J KrauseM Schwaiger
Nov 7, 2007·European Journal of Nuclear Medicine and Molecular Imaging·B Scher, M Seitz
Jul 3, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Abass Alavi, Sandip Basu
Jun 1, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Bernd J KrauseMarkus Schwaiger
Dec 5, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Jens SörensenSilvia Johansson
Apr 13, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Claudia BrogsitterJörg Kotzerke
May 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Kinzya GrantPeter L Choyke
Apr 9, 2009·Nature Reviews. Urology·Baris TurkbeyPeter L Choyke
Apr 7, 2007·Current Opinion in Oncology·Peter Oehr, Kirsten Bouchelouche
May 22, 2009·AJR. American Journal of Roentgenology·Baris TurkbeyPeter L Choyke
May 22, 2009·AJR. American Journal of Roentgenology·Gary J KelloffUNKNOWN Prostate Cancer Imaging Working Group
Nov 11, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andrea B ApoloMichael J Morris
Apr 22, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mark P S Dunphy, Jason S Lewis
Jul 18, 2014·PET Clinics·Georgios Karanikas, Mohsen Beheshti
Jul 31, 2012·Seminars in Nuclear Medicine·Carina Mari Aparici, Youngho Seo
Jun 19, 2012·Cancer Treatment Reviews·Gilles CréhangeMack Roach
May 31, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael SouvatzoglouHans Geinitz
Apr 13, 2011·International Journal of Radiation Oncology, Biology, Physics·Lisa K Morikawa, Mack Roach
Mar 11, 2011·Urologic Oncology·Bernd Joachim KrauseUwe Treiber
Nov 30, 2010·Seminars in Nuclear Medicine·Kirsten BouchelouchePeter Choyke
Jul 6, 2010·The Lancet Oncology·Ambros J BeerBernd Joachim Krause
Sep 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan SeppäläHeikki Minn
Apr 1, 2009·PET Clinics·Johannes CzerninMartin S Allen-Auerbach
May 6, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D PasquierP Masson
Nov 11, 2008·European Journal of Radiology·Gregory RavizziniPeter L Choyke
May 26, 2007·La Presse médicale·Jean-Noël TalbotPhilippe Thibault
Jun 28, 2012·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Nima NajmaeiMahdi Azizian
Aug 8, 2006·The Journal of Urology·Richard D Williams
Sep 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiaohong OuyangGuangli Jiao
Feb 22, 2012·European Journal of Radiology·Ivan JamborHeikki Minn
Mar 17, 2015·Nature Cell Biology·Lindsey K Boroughs, Ralph J DeBerardinis
May 26, 2016·Japanese Journal of Radiology·Kazuhiro KitajimaHossein Jadvar
Nov 9, 2016·Seminars in Nuclear Medicine·David M SchusterStefano Fanti
Feb 26, 2010·European Journal of Radiology·W Wadsak, M Mitterhauser
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joycelyn L Speight, Mack Roach

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