11C-choline PET/CT detects the site of relapse in the majority of prostate cancer patients showing biochemical recurrence after EBRT

European Journal of Nuclear Medicine and Molecular Imaging
Francesco CeciStefano Fanti

Abstract

The aim of this retrospective study was to evaluate the usefulness and the detection rate of (11)C-choline PET/CT in a population of patients with prostate cancer (PC), exclusively treated with external beam radiotherapy (EBRT) as primary treatment, who showed biochemical relapse. We enrolled 140 patients showing a serum PSA level >2 ng/mL (mean 8.6 ng/mL, median 5 ng/mL, range 2 - 60 ng/mL). All patients had been treated with EBRT to the prostate gland and prostatic fossa with doses ranging from 70 to 76 Gy in low-risk patients (T1/T2 and/or serum PSA <10 ng/mL) and escalating to >76 Gy (range 76 - 81 Gy) in high-risk patients (T3/T4 and/or serum PSA >10 ng/mL). Of the 140 patients, 53 were receiving androgen deprivation therapy at the time of the scan. All positive (11)C-choline PET/CT findings were validated by transrectal ultrasound-guided biopsy or at least 12 months of follow-up with contrast-enhanced CT, MR, bone scintigraphy or a repeated (11)C-choline PET/CT scan. The relationships between the detection rate of (11)C-choline PET/CT and the factors PSA level, PSA kinetics, Gleason score, age, time to relapse and SUV max in patients with positive findings were analysed. (11)C-Choline PET/CT detected the site of relapse i...Continue Reading

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Citations

Jun 27, 2014·BioMed Research International·Flavio Barchetti, Valeria Panebianco
Sep 4, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciStefano Fanti
Feb 9, 2016·International Journal of Radiation Oncology, Biology, Physics·Arndt-Christian MüllerUte Ganswindt
Nov 2, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·R Renard PennaM Soulié
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May 16, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciIrene J Virgolini
Jun 26, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·José López TorrecillaCarmen González San Segundo
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Jun 18, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo CastellucciStefano Fanti
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