(11)C-Choline PET/CT in castration-resistant prostate cancer patients treated with docetaxel

European Journal of Nuclear Medicine and Molecular Imaging
Francesco CeciStefano Fanti

Abstract

To investigate the role of (11)C-choline PET/CT for evaluating the response to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with docetaxel in comparison with PSA response. Inclusion criteria were (a) proven mCRPC, (b) docetaxel as first line of chemotherapy (docetaxel 75 mg/m(2) + prednisone 5 mg), and (c) (11)C-choline PET/CT and PSA values assessed before and after docetaxel administration. A total of 61 patients were retrospectively enrolled (mean age 68.9 years, range 57 - 84 years). (11)C-Choline PET/CT was performed at baseline before docetaxel treatment (PET1) and after the end of treatment (PET2). PSA values were measured before treatment (PSA1) and after treatment (PSA2). PET2 was reported as complete response (CR), partial response (PR) or stable disease (SD). Progressive disease (PD) was considered if a new lesion was seen. PSA trend was calculated from the change in absolute values between PSA1 and PSA2. A decrease of ≥50 % between PSA1 and PSA2 was considered a PSA response. Clinical, radiological and laboratory follow-up ranged from 6 to 53 months (mean 13.5 months). Of the 61 patients, 40 (65.5 %) showed PD on PET2, 13 (21.3 %) showed SD, 2 (3.4 %) showed PR, and 6 (9...Continue Reading

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Citations

Oct 24, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Laura Evangelista, Emilio Bombardieri
Mar 10, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Laura EvangelistaEmilio Bombardieri
Jun 10, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Tiziano GrazianiStefano Fanti
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Aug 26, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciStefano Fanti
Dec 21, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Bernhard GrubmüllerMarkus Hartenbach
Jan 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Giampiero GiovacchiniMaria Picchio
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May 26, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciStefano Fanti
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Mar 15, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Laura Evangelista, Pierpaolo Alongi
Oct 4, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francesco CeciStefano Fanti
Feb 26, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joohee LeeSandi A Kwee

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