PMID: 6171485Nov 1, 1981Paper

11C-L-methionine for evaluation of pancreatic exocrine function

Gut
André SyrotaA Paraf

Abstract

Pancreatic uptake of a natural amino acid, L-methionine, was measured in 58 patients using a scintillation camera. This was possible by labelling L-methionine with 11C, a short-lived isotope produced in a cyclotron. Time-activity-curves obtained in areas of interest selected over the pancreas in 25 normal subjects and in 14 alcoholic patients showed a plateau or a slight increase of activity with time. In contrast, in 19 patients with chronic pancreatitis an initial increase in radioactivity was followed by a decrease for 10 to 20 minutes and then by a plateau. The ratio of the height of the plateau at the 50th minute to the height of the peak was 0.74 +/- 0.21 in these patients, whereas it was 0.96 +/- 0.09 in the other subjects (P less than 0.001). This result was compared with direct measurements of 11C radioactivity and of amylase and bicarbonate in duodenal aspirate. The median amount of 11C incorporated into protein at the 70th minute was 53% of total activity in the control group, 28% in alcoholic patients, and only 3% in chronic pancreatitis, the differences between these values were highly significant. The absence of a peak of radioactivity in the duodenal juice, and the existence of a correlation between total 11C out...Continue Reading

References

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Citations

Nov 13, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Teemu KalliokoskiMerja Haaparanta-Solin
Mar 1, 1995·Gastroenterology·M E MailliardG E Mann
Mar 15, 2011·Lancet·Joan M BraganzaMichael J McMahon
Jul 9, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Emanuel SteinerJohannes Miholic
Feb 21, 2008·The Journal of Clinical Endocrinology and Metabolism·Teemu KalliokoskiOlli Simell

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