11C-Methionine-PET: a novel and sensitive tool for monitoring of early response to treatment in multiple myeloma

Oncotarget
Katharina LückerathAndreas K Buck

Abstract

Multiple myeloma (MM) remains an essentially incurable hematologic malignancy. However, new treatment modalities and novel drugs have been introduced and thus additional tools for therapy monitoring are increasingly needed. Therefore, we evaluated the radiotracers 11C-Methionine (paraprotein-biosynthesis) and 18F-FDG (glucose-utilization) for monitoring response to anti-myeloma-therapy and outcome prediction. Influence of proteasome-inhibition on radiotracer-uptake of different MM cell-lines and patient-derived CD138+ plasma cells was analyzed and related to tumor-biology. Mice xenotransplanted with MM.1S tumors underwent MET- and FDG-μPET. Tumor-to-background ratios before and after 24 h, 8 and 15 days treatment with bortezomib were correlated to survival. Treatment reduced both MET and FDG uptake; changes in tracer-retention correlated with a switch from high to low CD138-expression. In xenotransplanted mice, MET-uptake significantly decreased by 30-79% as early as 24 h after bortezomib injection. No significant differences were detected thus early with FDG. This finding was confirmed in patient-derived MM cells. Importantly, early reduction of MET- but not FDG-uptake correlated with improved survival and reduced tumor burden...Continue Reading

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Citations

May 4, 2017·British Journal of Haematology·Constantin LapaStefan Knop
Mar 15, 2016·Frontiers in Oncology·Amarnath Challapalli, Eric O Aboagye
Jun 24, 2016·Der Radiologe·M E Mayerhoefer, A Haug
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Jul 6, 2019·Clinical Nuclear Medicine·Constantin LapaSamuel Samnick
May 5, 2017·PloS One·Narinée HovhannisyanLouisa Barré
Apr 22, 2020·Neuroradiology·Francesca Di GiulianoMario Muto
Mar 7, 2021·Biomedicines·Janette IkingChristoph Rischpler
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Nov 6, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stefan KircherConstantin Lapa

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Methods Mentioned

BETA
imaging
X-ray
imaging techniques
biopsies
FACS
xenografts

Software Mentioned

SPSS
Image J
BD CellQuest
GeoMean
Medical Image Data Analysis Tool ( AMIDE )
PASW Statistics

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