11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism.

Langenbeck's Archives of Surgery
J HenningsP Hellman

Abstract

To evaluate whether dexamethasone suppression treatment can improve (11) C-metomidate positron emission tomography (MTO-PET) detection of small adrenocortical adenomas in primary aldosteronism (PA). Eleven patients with proven PA and two patients with non-hyperfunctioning adrenocortical incidentalomas and small adrenocortical tumours observed on CT underwent MTO-PET before and 3 days after administration of oral dexamethasone suppression treatment. Small "hot-spot" regions of interest comprising 4 pixels (SUVhs) and 1 pixel (SUVmax) were placed in the tumour area with the highest radioactivity concentration and their respective standardised uptake values (SUV) were recorded. All tumours were detected and categorised as adrenocortical by MTO-PET. SUVhs as well as SUVmax were higher in PA compared to nonfunctional adenomas. Normal adrenal cortex was suppressed after dexamethasone (p < 0.05), but tumour SUV was not significantly decreased after suppression in either PA or nonfunctional tumours (p > 0.05). However, these changes caused no significant increase in the tumour-to-normal adrenal ratio (p > 0.05). MTO-PET is a highly sensitive method for detecting and categorising even small adrenocortical tumours in PA. In this series, ...Continue Reading

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Citations

Aug 17, 2010·Langenbeck's Archives of Surgery·Bruno Niederle
Nov 2, 2011·Endocrine·Norlela Sukor
Nov 30, 2011·Hormones & Cancer·S Hahner, A Sundin
Oct 23, 2012·Indian Journal of Endocrinology and Metabolism·Punit Sharma, Rakesh Kumar
Jan 31, 2013·British Medical Bulletin·John R Buscombe, Bernadette Wong
Nov 22, 2016·Diagnostics·Iosif A MendichovszkyFiona J Gilbert
Apr 20, 2017·International Journal of Molecular Sciences·Fabrizio BuffoloPaolo Mulatero
Mar 14, 2018·American Journal of Hypertension·Ryo MorimotoFumitoshi Satoh
Jan 31, 2016·Clinical Nuclear Medicine·Ka Kit WongMilton D Gross
Apr 9, 2020·Endocrine Reviews·Mark SherlockPaul M Stewart
Feb 23, 2017·Langenbeck's Archives of Surgery·Marcello Di MartinoLuis Domínguez Gadea
Nov 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Pia BurmanUlrika Bitzén
Apr 29, 2021·EJNMMI Physics·Daniel GillettLuigi Aloj

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