PMID: 2502181Jul 21, 1989Paper

1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels in rat distal colonic mucosa: effects of 2-difluoromethylornithine

Biochimica Et Biophysica Acta
A G HallineT A Brasitus

Abstract

Recently, our laboratory has demonstrated that N1-acetylspermidine levels were increased in the distal colonic mucosa of rats administered 1,2-dimethylhydrazine for 15 and 26 weeks. In order to further explore the possible role of this acetylated polyamine in the malignant transformation process induced by this carcinogen, groups of rats were subcutaneously injected weekly with dimethylhydrazine (20 mg/kg body wt.) or diluent for 5, 10, 15 and 26 weeks +/- 1% 2-difluoromethylornithine in the drinking water. The latter agent, an irreversible inhibitor of ornithine decarboxylase, has previously been shown to inhibit colonic tumor formation in this experimental model. At each of these time periods, rats from each group were killed, their proximal and distal colonic mucosa harvested and examined, and compared with respect to polyamine levels, including N1-acetylspermidine, as well as the activities of ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine N1-acetyltransferase and polyamine oxidase. The results of these experiments demonstrated that: (1) N1-acetylspermidine levels in the proximal colonic segment of all animals were similar at each time point; (2) N1-acetylspermidine levels were also similar in the d...Continue Reading

References

Nov 1, 1987·The Journal of Surgical Research·F L GreeneM Barwick
Oct 1, 1987·Canadian Journal of Physiology and Pharmacology·N Seiler
Aug 19, 1987·Biochimica Et Biophysica Acta·C StefanelliC M Caldarera
Sep 6, 1985·Biochimica Et Biophysica Acta·R M Steeves, D E Lawson
Jul 1, 1968·The Biochemical Journal·A E Pegg, H G Williams-Ashman
Jan 1, 1981·Advances in Cancer Research·G Scalabrino, M E Ferioli
Jul 16, 1982·Biochemical and Biophysical Research Communications·S MatsuzakiK Matsuura
Dec 31, 1982·Biochemical and Biophysical Research Communications·C DanzinJ Grove

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Citations

Jan 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yair Bar DavidJoseph Kapelushnik

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