PMID: 7519976Apr 1, 1994Paper

12-lead and continuous ECG recordings of subjects during inpatient administration of smoked cocaine

Drug and Alcohol Dependence
P R PentelD M Salerno

Abstract

Cocaine can cause myocardial ischemia or infarction. The incidence of these events, and the influence of specific dosing routes or regimens on their occurrence is not established. In the current study, we obtained frequent 12-lead electrocardiograms (ECGs) and continuous 2 or 3 channel ECGs from 20 subjects participating in a behavioral study of smoked cocaine. Subjects received 10 or 11 doses of cocaine 0.4 mg/kg per dose, or 10 doses of 35 mg per dose at 30 min intervals (range 233-408 mg total dose per session). ECGs were also recorded on control days on which subjects received no cocaine. The mean peak plasma cocaine concentration on cocaine days was 640 +/- 262 ng/ml. There were no changes in digitized ST segment amplitude on 12-lead ECGs obtained during cocaine administration (P = 0.098). Of 17 subjects who had technically satisfactory continuous ECGs, four had significant ST segment depression (> 1 mm below the PR segment); two on cocaine days and two on control days (P > 0.5). One subject had frequent premature beats on both cocaine and control days. One subject had an asymptomatic run of 4 ventricular beats 30 s after cocaine administration that could have been due to cocaine. All episodes of ST depression or premature...Continue Reading

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Citations

Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·D E KeylerP R Pentel
Jun 5, 2003·Heart Disease·William H FrishmanAnjum Ismail
Dec 14, 2011·Expert Review of Cardiovascular Therapy·F Daniel RamirezAdrian Baranchuk
Apr 18, 2006·The American Journal of Cardiology·Anthony R MagnanoHasan Garan

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