12-Month stability of neurological soft signs in stabilized patients with schizophrenia

Nordic Journal of Psychiatry
Konstantinos N FountoulakisIoannis Nimatoudis

Abstract

Objective: Neurological soft signs (NSS) are a group of minor non-localizable neurological abnormalities found more often in patients with schizophrenia. The aim of the current study was to investigate their temporal stability and relationship to the overall outcome over a 12-month period. Material and methods: The study sample included 133 stabilized patients suffering from schizophrenia (77 males and 56 females; aged 33.55 ± 11.22 years old). The assessment included the application at baseline and after 12 months of the Neurological Evaluation Scale (NES), and a number of scales assessing the clinical symptoms and adverse effects. The statistical analysis included ANOVA, exploratory t-test and Pearson correlation coefficients with Bonferroni correction. Results: In stabilized patients, NSS are stable over a 12-month period with only the subscale of NES-sensory integration manifesting a significant worsening, while, in contrast, most of the clinical variables improved significantly. There was no relationship of NES scores with the magnitude of improvement. The only significant negative correlation was between NES-motor coordination and Positive and Negative Syndrome Scale-GP change at 1 year. Discussion: The results of the cur...Continue Reading

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Citations

Aug 19, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sofia FinsterwalderMarco Duering
Nov 30, 2021·European Archives of Psychiatry and Clinical Neuroscience·Konstantinos N FountoulakisIoannis Nimatoudis

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