12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

Mediators of Inflammation
Nathalie DeckxN Cools

Abstract

Previously, we reported that patients with multiple sclerosis (MS) demonstrate improved muscle strength, exercise tolerance, and lean tissue mass following a combined endurance and resistance exercise program. However, the effect of exercise on the underlying disease pathogenesis remains elusive. Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. We demonstrate an increased number of plasmacytoid DC (pDC) following the exercise program. These pDC display an activated phenotype, as evidenced by increased numbers of circulating CD62L(+) and CD80(+) pDC. Interestingly, the number of CD80(+) pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. In addition, decreased production of the inflammatory mediators, TNF-α and MMP-9, upon Toll-like receptor (TLR) stimulation was found at the end of the exercise program. Overall, our findings suggest that the 12-week exercise program reduces the secretion of inflammatory mediators upon TLR stimulation and promotes the...Continue Reading

Associated Clinical Trials

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Citations

Jan 11, 2018·International Journal of Molecular Sciences·Winde JorissenJerome J A Hendriks
Feb 9, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R NegareshJ S Baker
Aug 2, 2019·Annals of Clinical and Translational Neurology·Nina FainsteinOfira Einstein
Jun 7, 2018·Frontiers in Behavioral Neuroscience·Barbara WillekensNathalie Cools
Jul 28, 2020·Reviews in the Neurosciences·Berenice Anabel SilvaCarina Cintia Ferrari
May 1, 2021·International Journal of Environmental Research and Public Health·Laura EsquiusNúria Lloberas
Feb 17, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Arthur R ChavesMichelle Ploughman

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Methods Mentioned

BETA
density gradient purification
ELISA
flow cytometry

Clinical Trials Mentioned

NCT01718392
NCT01845896

Software Mentioned

SAS
FlowJo
GraphPad
REVAL

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