12-year changes in cardiovascular risk factors in people with major depressive or bipolar disorder: a prospective cohort analysis in Germany

European Archives of Psychiatry and Clinical Neuroscience
Sven SpeerforckG Schomerus

Abstract

Major depressive disorder (MDD) and bipolar disorder are associated with certain cardiovascular risk factors (CVRFs), but it is unclear whether they are associated with unfavourable changes of clinically manifest CVRFs over time. We used baseline and 12-year follow-up (n = 1887) data from the German Health Interview and Examination Survey 1998. Multivariable linear regression models assessed associations between lifetime CIDI-diagnosed mood disorders at baseline and continuous risk factor-related outcomes (blood pressure, HbA1c, LDL-C, HDL-C, triglycerides, BMI) at follow-up. We did not find consistent deterioration of CVRFs in persons with compared to persons without MDD. Analyses pointed to severity of mood disorder as an important correlate of long-term changes of comorbid hypertension: while a history of mild MDD was not associated with changes in CVRFs, moderate MDD was associated with lower blood pressure [systolic: β = - 7.5 (CI - 13.2; - 1.9); diastolic: β = - 4.5 (CI - 7.8; - 1.3)] and a history of bipolar disorder was associated with higher systolic blood pressure at follow-up (β = 14.6; CI 4.9-24.4). Further, severe MDD was weakly associated with a higher BMI at follow-up [β = 1.2 (CI 0.0; 2.4)]. These outcomes were ...Continue Reading

References

Jan 11, 1992·BMJ : British Medical Journal·J A PilgrimM Marmot
Apr 20, 2000·Psychosomatic Medicine·B S Jonas, J F Lando
Jul 27, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S PaternitiA Alpérovitch
Nov 23, 2000·Archives of Internal Medicine·P S CiechanowskiJ E Russo
Mar 20, 2001·Archives of General Psychiatry·B W PenninxW van Tilburg
Aug 3, 2001·American Journal of Hypertension·E H ShinnJ P Foreyt
Jan 12, 2002·Archives of General Psychiatry·Ramin MojtabaiDavid Mechanic
Jul 3, 2002·American Journal of Preventive Medicine·Reiner Rugulies
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Aug 2, 2003·Biological Psychiatry·Bruce S McEwen
Oct 23, 2003·JAMA : the Journal of the American Medical Association·Lijing L YanCatarina I Kiefe
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Sep 24, 2004·Bipolar Disorders·Amy M KilbourneGretchen L Haas
Dec 22, 2006·Journal of Epidemiology and Community Health·Bjørn HildrumJostein Holmen
Apr 11, 2007·Psychosomatic Medicine·Anastasia GeorgiadesRichard S Surwit
Aug 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Bjørn HildrumAlv A Dahl
Nov 27, 2008·JAMA : the Journal of the American Medical Association·Mary A WhooleyWarren S Browner
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association
Jun 30, 2009·Psychosomatic Medicine·Jess G FiedorowiczWilliam H Coryell
Aug 20, 2009·Bipolar Disorders·Benjamin I GoldsteinDavid J Kupfer
Nov 7, 2009·American Journal of Hypertension·James E GangwischThomas G Pickering
Mar 3, 2010·Archives of General Psychiatry·Floriana S LuppinoFrans G Zitman
Jan 12, 2011·Statistical Methods in Medical Research·Shaun R Seaman, Ian R White
Apr 20, 2011·The Australian and New Zealand Journal of Psychiatry·Nicolas J C StapelbergIan Hamilton-Craig
Jun 2, 2011·Biometrics·Tyler J VanderWeele, Ilya Shpitser
Jul 27, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jessica M BrownChristopher M Callahan
Jan 12, 2012·PloS One·Giovanni CizzaUNKNOWN P.O.W.E.R. (Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression) Study Group

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Citations

Jun 30, 2019·European Archives of Psychiatry and Clinical Neuroscience·Andrea SchmittPeter Falkai
Feb 2, 2021·International Journal of Bipolar Disorders·Niall M McGowanKate E A Saunders
Aug 19, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Magdalena BeranUNKNOWN European Depression in Diabetes (EDID) Research Consortium

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