12 Year Trajectories of Depressive Symptoms in Community-Dwelling Older Adults and the Subsequent Risk of Death Over 13 Years

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Saira Saeed MirzaHenning Tiemeier

Abstract

Populations of depressed persons are typically comprised of individuals with different courses of depression and thus might carry different risks of death. This study aimed to identify different trajectories of depressive symptoms in community-dwelling older adults and study the risk of death across these trajectories. In the population-based Rotterdam Study, depressive symptoms (Center for Epidemiological Studies-Depression scale) at three examination rounds (1993-2004) from 3,325 dementia-free participants (mean age 64.6 ± 6.1 years) were used to identify depression trajectories by latent-class trajectory modeling. Mortality rates by trajectory were calculated over a subsequent 13 year period (2002-2015), that is using 23 years of follow-up data. Five trajectories of depressive symptoms characterized by low (73.4%), decreasing (11.1%), remitting (5.1%), increasing (7.7%), and high (2.7%) depressive symptoms were identified. Compared with persons in the low symptoms trajectory, persons with a trajectory of increasing depressive symptoms (hazard ratio [HR]: 1.21 [95% CI = 1.02, 1.44]) had a higher risk of death, but not those with remitting depressive symptoms, HR: 1.06 (95% CI = 0.85, 1.32). The estimates for the high symptoms...Continue Reading

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Citations

Oct 8, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Haibin LiXiuhua Guo
Jun 11, 2019·International Journal of Geriatric Psychiatry·Xiaoling Xiang, Jianjia Cheng
May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Jul 1, 2020·International Psychogeriatrics·Aarti GuptaRajesh R Tampi
Dec 2, 2020·Scientific Reports·Tomáš FormánekPavla Cermakova
Nov 11, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Rachel PruchnoFrancine Cartwright
Jun 22, 2021·Aging & Mental Health·Ignacio Madero-CabibJosefa Guerra

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