1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients

Genetics and Molecular Research : GMR
S A Gutierrez-RubioA Daneri-Navarro

Abstract

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification. Molecular subtypes as well as allele and genotype frequencies were analyzed. A total of 248 women with initial breast cancer diagnosis and 180 ethnically matched, healthy, unrelated individuals were enrolled. Polymerase chain reaction-restriction fragment length polymorphism was performed to detect polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene. Premenopausal T allele carriers of the 3435 C/T polymorphism showed a 2-fold increased risk of breast cancer with respect to the reference and postmenopausal groups, as well as triple-negative expression regarding the luminal A/B molecular subrogated subtypes. In contrast, the CT genotype of the 1236 polymorphism was a protective factor against breast cance...Continue Reading

Citations

Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guangli YinKourong Miao
Feb 20, 2019·Genes·Valentina A ZavalaLaura Fejerman
Aug 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying NiHairong Qiu
Nov 15, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Filipa LynceSusan T Vadaparampil
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Ali M AbuhaliemaKhalil Z Al Majdalawi
Mar 3, 2019·Molecular and Cellular Biochemistry·Nahla E El-AshmawyMariam A Abo-Saif

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