123I-labelled vasoactive intestinal peptide receptor scintigraphy in patients with colorectal cancer

British Journal of Cancer
Markus RadererI Virgolini

Abstract

Recent studies have shown that various gastrointestinal tumours express substantial amounts of vasoactive intestinal peptide (VIP) receptors. Based on these observations, we have developed a receptor scintigraphy using [123I]VIP as a radioligand. An initial series performed at our institution showed promising potential for visualization of various gastrointestinal adenocarcinomas by means of [123I]VIP. In this article, we now report the results obtained in 80 consecutive patients with colorectal adenocarcinoma. Eighty consecutive patients with histologically verified colorectal cancer underwent scanning by means of [123I]VIP (1 microg, approximately 150 MBq). Thirteen patients were free of tumour after complete resection of Dukes' C cancer, eight patients presented with primary and 14 with locally recurrent tumours but were free of metastases. Ten patients had locally recurrent disease and liver, lung or lymph node metastases. Disease confined to organ metastases (i.e. liver, lung or lymph nodes) was present in 35 patients. The size of the primary or recurrent tumours ranged between 3 and 6 cm, and the size of metastases was between 1 and 13 cm in diameter. Scan results were evaluated independently by two nuclear medicine physi...Continue Reading

Citations

May 19, 2000·Annals of Surgery·R A EhlersB Mark Evers
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Georg Riccabona, Clemens Decristoforo
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bieke Van Den Bossche, Christophe Van de Wiele
Nov 18, 2004·Journal of the National Cancer Institute·Richard D KennedyD Paul Harkin
Feb 1, 2014·International Journal of Oncology·Bo TangShi-Ming Yang
Dec 26, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Terry W MoodyRobert T Jensen
Nov 18, 2003·Endocrinology·Anthony J HarmarJean Claude Reubi
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Christophe Van de WieleRudi Andre Dierckx
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M RadererI Virgolini
Apr 20, 2013·Journal of Medicinal Chemistry·Felix Gonzalez-Lopez de TurisoSteven H Olson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.