(123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies

Ageing Research Reviews
Satoshi OrimoHirohisa Watanabe

Abstract

Cardiac meta-iodobenzylguanidine (MIBG) uptake on (123)I-MIBG cardiac scintigraphy is reduced in patients with Lewy body disease such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure, and has been reported to be useful for differentiating PD from other parkinsonian syndromes, as well as DLB from Alzheimer disease (AD). Postmortem studies have shown that the number of tyrosine hydroxylase (TH)-immunoreactive nerve fibers of the heart was decreased in pathologically-confirmed Lewy body disease, supporting the findings of reduced cardiac MIBG uptake in Lewy body diseases. Now, reduced cardiac MIBG uptake can be a potential biomarker for the presence of Lewy bodies in the nervous system. (123)I-MIBG cardiac scintigraphy can allow us to determine the presence of Lewy bodies.

References

Feb 1, 1986·The American Journal of Cardiology·R D JanesJ A Armour
Mar 6, 1997·The New England Journal of Medicine·D S GoldsteinI J Kopin
Jan 17, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S Braune
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·S OrimoM Yokochi
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Jan 23, 2004·Brain : a Journal of Neurology·Amanda SingletonDavid S Goldstein
May 14, 2004·Journal of the Neurological Sciences·Shinji SaikiMiho Miaki
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·H NagayamaY Katayama
Feb 11, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Masahiko SuzukiKiyoharu Inoue
Jul 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Satoshi OrimoYoshikuni Mizuno
Jul 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Juan J ZarranzPedro Madoz
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Jan 27, 2006·Annals of Neurology·Benoit I GiassonVivianna M Van Deerlin
Feb 9, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Shigeki NagamachiHideyuki Wakamatsu
Sep 23, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Joong-Seok KimHee-Tae Kim
Jun 15, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Phil Hyu LeeYun Joong Kim
Dec 20, 2007·Neuroreport·Masahiko SuzukiKenichiro Taira
Apr 2, 2008·Journal of the Neurological Sciences·Joong-Seok KimHee-Tae Kim
Apr 10, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Hiroshi NagayamaOsamu Mori
Jun 3, 2008·Parkinsonism & Related Disorders·Richard ImrichDavid S Goldstein
Jul 25, 2008·Nature Clinical Practice. Cardiovascular Medicine·Jeanne M Link, James H Caldwell
Sep 23, 2008·Parkinsonism & Related Disorders·Kazuko HasegawaSaburo Yagishita
Jan 13, 2009·Neurobiology of Aging·Fabiana NovellinoAldo Quattrone
Oct 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Yasuo MikiSatoshi Orimo
Feb 23, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Charles H AdlerThomas G Beach
Oct 23, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·M Marquié SayaguésA Lleó Bisa
Nov 26, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Koichi OkudaSeigo Kinuya
Feb 15, 2011·Parkinson's Disease·Asako YoritakaNobutaka Hattori
Feb 19, 2011·Journal of Neural Transmission·Hisayoshi OkaSoichiro Mochio

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Citations

Apr 14, 2016·Current Neurology and Neuroscience Reports·Per BorghammerDavid J Brooks
Apr 1, 2017·Translational Neurodegeneration·Usman SaeedMario Masellis
Jan 11, 2017·Journal of Neuropathology and Experimental Neurology·John M LeeThomas G Beach
Jun 27, 2017·NPJ Parkinson's Disease·Per BorghammerDavid J Brooks
Jan 13, 2019·BMC Neurology·Kazumasa ShindoYoshihisa Takiyama
Oct 27, 2018·Frontiers in Aging Neuroscience·Runcheng HeQiying Sun
Sep 21, 2018·Current Neurology and Neuroscience Reports·Karoline Knudsen, Per Borghammer
Sep 19, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G RobertsA J Thomas
Oct 4, 2020·Alzheimer Disease and Associated Disorders·Melissa J ArmstrongJames E Galvin
Feb 18, 2020·Current Pharmaceutical Design·Mohan K GhantaBhaskar L V K S
Jun 16, 2021·Wiener medizinische Wochenschrift·Sigrid Klotz, Ellen Gelpi
Jul 3, 2021·Behavioral Sciences·Ángela Milán-TomásMaría Cruz Rodríguez-Oroz
Feb 5, 2019·ACS Chemical Neuroscience·Ling-Yan MaTao Feng
Nov 25, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fabian LeysAlessandra Fanciulli

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