PMID: 8940711Aug 1, 1996Paper

123I-vasoactive intestinal peptide (VIP) receptor scanning: update of imaging results in patients with adenocarcinomas and endocrine tumors of the gastrointestinal tract

Nuclear Medicine and Biology
Irene VirgoliniP Valent

Abstract

Recent data suggest that functional receptors (R) for vasoactive intestinal peptide (VIP) are expressed on various tumor cells. The high-level expression of VIPR on tumor cells provided the basis for the successful use of 123I-labeled VIP for the in vivo localization of intestinal adenocarcinomas and endocrine tumors. We here report an update of our imaging results using 123I-VIP (150-200 MBg/1 microgram/patient) in 169 patients. In patients with pancreatic adenocarcinomas without liver metastases, the primary/recurrent tumor was visualized in 16 of 18 patients (89%) and liver metastases were imaged in 15 of 16 patients. In 11 of 12 patients with colorectal adenocarcinomas, the primary/recurrent tumor (92%) was imaged by 123I-VIP. Also, in 21 of 25 patients, liver metastases (84%); in 3 of 6 patients, lung metastases (50%); and in 4 of 5 patients, lymph-node metastases (80%) were imaged by 123I-VIP. In 10 of 10 patients with gastric adenocarcinomas, the primary/recurrent tumor; in 3 of 4 patients, liver metastases; and in 2 of 2 patients, lymph-node metastases were visualized by 123I-VIP. 123I-VIP localized primary intestinal carcinoid tumors in 15 of 17 patients (88%) and 8 of 10 primary insulinomas (80%). We conclude that the...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y YamadaS Seino
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P SreedharanE J Goetzl
Sep 1, 1990·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·C R Smart
Nov 1, 1990·The New England Journal of Medicine·S W LambertsE P Krenning
Sep 11, 1986·The New England Journal of Medicine·L K KvolsR G Hahn
Jan 1, 1989·Molecular Neurobiology·I Gozes, D E Brenneman
Jan 1, 1988·Annals of the New York Academy of Sciences·M Laburthe, A Couvineau
Jul 1, 1985·The Journal of Clinical Endocrinology and Metabolism·A Couvineau, M Laburthe
Jul 7, 1973·Lancet·S R BloomA G Pearse
Dec 15, 1983·The New England Journal of Medicine·S Reichlin
Dec 22, 1983·The New England Journal of Medicine·S Reichlin
Oct 1, 1995·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·I VirgoliniP Valent
Dec 30, 1994·Biochemical and Biophysical Research Communications·M SvobodaP Robberecht
Sep 15, 1994·Annals of the New York Academy of Sciences·E P KrenningA E Reijs
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·N InagakiS Seino
Apr 29, 1994·Biochemical and Biophysical Research Communications·A CouvineauM Laburthe
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D J WagenerJ A Wils
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L RohrerR Schüle
Sep 1, 1958·The American Journal of Medicine·J V VERNER, A B MORRISON

❮ Previous
Next ❯

Citations

Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Vijay SharmaDavid Piwnica-Worms
Feb 6, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Marion de JongEric P Krenning
Apr 23, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Jean Claude Reubi, Beatrice Waser
Mar 15, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Irene VirgoliniClemens Decristoforo
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Georg Riccabona, Clemens Decristoforo
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Guo-Hua LiXiao-Hua Hou
Jan 25, 2014·BioMed Research International·Dengfeng ChengHongcheng Shi
Jun 6, 2007·Hematology/oncology Clinics of North America·Eric P TammChaan S Ng
May 22, 2004·Annals of the New York Academy of Sciences·Eric P KrenningMarion De Jong
Feb 25, 2015·Cancer Biotherapy & Radiopharmaceuticals·Ashutosh DashFurn F Russ Knapp
Aug 6, 2000·Seminars in Nuclear Medicine·O C BoermanF H Corstens
Sep 19, 2016·Abdominal Radiology·Sampanna Jung RayamajhiPriya Bhosale
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bieke Van Den Bossche, Christophe Van de Wiele
Jan 7, 2010·Journal of Drug Targeting·Anna OrtnerAndreas Zimmer
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Christophe Van de WieleRudi Andre Dierckx
Jan 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christophe Van de WieleRudi Andre Dierckx
Nov 22, 2001·Bioconjugate Chemistry·M LangerA G Beck-Sickinger
Nov 5, 1997·Bioconjugate Chemistry·S LiuJ A Barrett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Irene VirgoliniP Valent
© 2021 Meta ULC. All rights reserved