123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia

Movement Disorders : Official Journal of the Movement Disorder Society
Markus NaumannT Brücke

Abstract

The radiotracer [123I]beta-CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]beta-CIT single-photon emission computed tomography (SPECT) findings in a patient with DOPA-responsive dystonia (DRD). [123I]beta-CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile-onset parkinsonism with dystonia that have a considerable poorer prognosis. [123I]-beta-CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.

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Citations

Jul 17, 2001·Nuclear Medicine Communications·K Tatsch
Aug 9, 2016·Rinshō shinkeigaku = Clinical neurology·Chiharu YasudaHiroaki Adachi
Dec 16, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Vicky Marshall, Donald Grosset
Aug 31, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Carles GaigFernando Nakamae
Nov 3, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Hasmet Ayhan HanagasiMurat Emre
Apr 28, 2015·Movement Disorders Clinical Practice·Subhashie WijemanneJoseph Jankovic
Sep 2, 1998·Current Opinion in Neurology·S B Bressman
Jul 6, 2019·Parkinsonism & Related Disorders·Nicki Niemann, Joseph Jankovic
Sep 6, 2018·Parkinsonism & Related Disorders·Stéphane ThoboisEmmanuel Broussolle
Jul 19, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Klaus Tatsch, Gabriele Poepperl
May 29, 2012·Pediatric Neurology·Eduardo López-LasoRachel Saunders-Pullman

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