PMID: 9447566Feb 3, 1998Paper

123Iodo-MK-801: a spect agent for imaging the pattern and extent of glutamate (NMDA) receptor activation in Alzheimer's disease

Journal of Psychiatric Research
D R BrownJ McCulloch

Abstract

Glutamate, and the NMDA glutamate receptor, may be involved in Alzheimer's Disease (AD). Reductions in NMDA receptors are found in AD, possibly contributing to memory deficits. However the NMDA receptor is involved in excitotoxicity, which may play a role in cell death and the production of neurofibrillary tangles in AD; although with lower levels of glutamate than occur in cerebral ischaemia. Therefore reductions in the NMDA receptor may worsen memory deficit in AD, but increased stimulation of the receptor may contribute to the progress of the disease. MK-801 has been used to image excessive glutamate activation following ischaemia in rats. However, it is unclear how effective MK-801 is in conditions with lower levels of glutamate release. This study attempts to gain insight into the utility of the tracer in these conditions, exploring glutamatergic mechanisms in AD. It describes the retention and elimination of 123iodo-MK-801 in five AD and five control subjects, comparing this to regional cerebral blood flow (rCBF). The initial uptake of 123I-MK-801 is dominated by delivery of the ligand. However, despite significant reductions in rCBF in the AD patients, there is no significant difference in the uptake of 123I-MK-801. This...Continue Reading

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Citations

Aug 12, 2008·Molecular Neurobiology·Victor L VillemagneChristopher C Rowe
Dec 31, 2003·Nuclear Medicine and Biology·Rikki N Waterhouse
Nov 2, 2004·Biological & Pharmaceutical Bulletin·Toshio NarahashiJay Zeus Yeh
Dec 24, 2015·Oxidative Medicine and Cellular Longevity·Rachelle Balez, Lezanne Ooi
Jan 22, 2004·Seminars in Nuclear Medicine·Satoshi MinoshimaDavid E Kuhl
Feb 22, 2005·Nuclear Medicine Communications·Sally L Pimlott
Jun 14, 2003·The Journal of Pharmacology and Experimental Therapeutics·Shigeki MoriguchiToshio Narahashi
Dec 31, 2002·Journal of Receptor and Signal Transduction Research·Marko KokicSimon M Ametamey
May 1, 2021·Cells·Dominic QuintanaJames Simpkins
Feb 15, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Colm J McGinnityJohn S Duncan

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