1,2,4-Triazole-aided native chemical ligation between peptide-N-acyl-N'-methyl-benzimidazolinone and cysteinyl peptide

Chemical Communications : Chem Comm
Ken SakamotoTaku Yoshiya

Abstract

1,2,4-Triazole facilitated native chemical ligation (NCL) between peptide-MeNbz (MeNbz: N-acyl-N'-methyl-benzimidazolinone) and a cysteinyl peptide in the absence of thiol additives. The method enabled one-pot desulfurization and iodine oxidation after NCL. Additionally, the direct isolation of the target peptide from the NCL reaction mixture with an activated thiopropyl-Sepharose resin was achieved.

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Citations

Apr 20, 2019·Chembiochem : a European Journal of Chemical Biology·Shugo TsudaTaku Yoshiya
Feb 28, 2019·Chembiochem : a European Journal of Chemical Biology·Taku YoshiyaShun Masuda
Aug 7, 2018·The Journal of Organic Chemistry·Bengt H Gless, Christian A Olsen
Jan 21, 2022·Chemistry : a European Journal·Vincent DiemerOleg Melnyk

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