124I-MIBG: a new promising positron-emitting radiopharmaceutical for the evaluation of neuroblastoma

Nuclear Medicine Review. Central & Eastern Europe
Angelina CistaroUmberto Ficola

Abstract

Neuroblastoma is the most common extra-cranial solid tumor in pediatric patients. Despite the established role of 123I-MIBG and 131I-MIBG scintigraphy in this tumor, only limited data are available regarding the use of 124I-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT). We present our preliminary experience with 124I-MIBG PET/CT: two pediatric patients affected by neuroblastoma, who underwent 124I-MIBG PET/CT for pre-therapy distribution evaluation and restaging purposes. We aimed to evaluate whether 124I-MIBG PET/CT can detect as many or more neuroblastoma lesions than 123I/131I-MIBG imaging. Our cases show promising results, although further validation and standardization of 124I-MIBG PET/CT are required.

Citations

Apr 5, 2016·Annals of Neurology·Nancy RatnerNina F Schor
May 5, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R ParkDominique Valteau-Couanet
Jun 26, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Zvi Bar-SeverFrancesco Giammarile
Jul 27, 2018·The British Journal of Radiology·Archi AgrawalNilendu Purandare
Jan 24, 2017·Journal of Radioanalytical and Nuclear Chemistry·Michael GreenGavin Brown
Mar 9, 2017·Medical Physics·Casper BeijstHugo W A M de Jong
Aug 6, 2018·Pediatric Radiology·Alan M ChenAlexander J Towbin
Jun 25, 2019·Nuclear Medicine and Molecular Imaging·Youngho Seo
Sep 5, 2019·Cancers·Clément BaillyThomas Carlier
Oct 24, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jia XiaAi-Guo Liu
Sep 10, 2020·Nuclear Medicine and Biology·Heinz H Coenen, Johannes Ermert
Feb 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ana Margarida AbrantesMaria Filomena Botelho
Oct 23, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Trevor FerrisEric O Aboagye
May 1, 2021·Journal of Personalized Medicine·Atia SamimBart de Keizer
Oct 19, 2017·Journal of Nuclear Medicine Technology·Casper BeijstHugo W A M de Jong
Sep 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arnoldo PiccardoEgesta Lopci
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Neeta Pandit-Taskar, Shakeel Modak
Dec 4, 2020·Journal of Medicinal Chemistry·Pavel ŠvecMartin Hrubý

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