1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway

The Journal of Steroid Biochemistry and Molecular Biology
G WongR S Mason

Abstract

1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is anti-apoptotic in human keratinocytes, melanocytes and fibroblasts after ultraviolet (UV)-exposure. To date, there is no published data on the effects of 1,25(OH)(2)D(3) or its analogs on DNA damage in irradiated skin cells. In these skin cells, 24h pre-treatment with 1,25(OH)(2)D(3) dose-dependently (10(-12) to 10(-8)M) decreased CPD damage by up to 60%. This photoprotective effect was also seen if the 1,25(OH)(2)D(3) was added immediately after irradiation and was mimicked by QW-1624F2-2 (QW), a low-calcemic 1beta-hydroxymethyl-3-epi-16-ene-24,24-difluoro-26,27-bis homo hybrid analog. The well-studied low calcemic, rapid acting agonist analogs 1alpha,25(OH)(2)lumisterol(3) (JN) and 1alpha,25(OH)(2)-7-dehydrocholesterol (JM) also protected skin cells from UV-induced cell loss and CPD damage to an extent comparable with that of 1,25(OH)(2)D(3). In contrast, the rapid response antagonist analog 1beta,25(OH)(2)D(3) (HL) completely abolished the photoprotective effects (reduced cell loss and reduced CPD damage) produced by treatment with 1,25(OH)(2)D(3), JN, JM and QW. Evidence for involvement of the nitric oxide pathway in the protection from CPD damage by 1,25(OH)(2)D(3) was obtain...Continue Reading

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Citations

Oct 17, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Clare Gordon-ThomsonRebecca S Mason
Aug 22, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Katie M DixonRebecca S Mason
Jan 5, 2008·Photochemistry and Photobiology·H Konrad MullerGregory M Woods
Jan 27, 2012·Photochemistry and Photobiology·Joshua A DesotelleNihal Ahmad
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Feb 11, 2012·Molecular Endocrinology·Vanessa B SequeiraRebecca S Mason
Jan 22, 2013·International Journal of Molecular Sciences·Katie M DixonRebecca S Mason
Nov 20, 2012·Future Medicinal Chemistry·Atsushi KittakaTai C Chen
Nov 2, 2013·Indian Journal of Dermatology, Venereology and Leprology·Khalid AlGhamdiNoura Moussa
Jan 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·K M DixonR S Mason
Oct 16, 2012·Journal of the American Academy of Dermatology·Jean Y TangMaryam M Asgari
Mar 1, 2012·Mutation Research·Visalini Nair-ShallikerMichael Fenech
Oct 27, 2010·The International Journal of Biochemistry & Cell Biology·Chunping YuMichele A Grimbaldeston
Apr 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·R S MasonV E Reeve
Dec 16, 2006·The Journal of Investigative Dermatology·Ritu GuptaRebecca S Mason
Aug 30, 2008·The International Journal of Biochemistry & Cell Biology·Katie M Dixon, Rebecca S Mason
Feb 3, 2009·Molecular Carcinogenesis·Haibo XuFrederick C Campbell
Jan 22, 2008·Clinical and Experimental Dermatology·L A KuritzkyP H Hart
Jun 20, 2007·Experimental Dermatology·Jörg Reichrath
Sep 18, 2009·Experimental Dermatology·Diona L DamianRebecca S Mason
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Natalie NemazannikovaCrispin R Dass
Jan 30, 2013·Molecular Carcinogenesis·Natalie NemazannikovaCrispin R Dass
Nov 29, 2013·Photodermatology, Photoimmunology & Photomedicine·Suzanne M PilkingtonLesley E Rhodes
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Dec 9, 2015·Journal of Advanced Research·Wedad Z Mostafa, Rehab A Hegazy
Feb 5, 2014·Dermato-endocrinology·Wannit Tongkao-OnRebecca S Mason
Nov 21, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Eric J SongRebecca S Mason
Jul 26, 2005·The Journal of Steroid Biochemistry and Molecular Biology·K M DixonR S Mason
Oct 11, 2017·American Journal of Clinical Dermatology·Elio Kechichian, Khaled Ezzedine
Sep 25, 2004·Journal of Cellular Biochemistry·Petra De HaesSiegfried Segaert
Jul 7, 2019·Pharmaceutics·Ye BiLesheng Teng
Feb 26, 2020·Redox Report : Communications in Free Radical Research·Shemani Vishalya Jagoda, Katie Marie Dixon
Jul 16, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Christina Bergqvist, Khaled Ezzedine
May 23, 2020·Cell Biochemistry and Biophysics·Andrzej T SlominskiRobert C Tuckey

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