1,25-Dihydroxyvitamin D maintains bone cell activity, and parathyroid hormone modulates bone cell number in dogs

Endocrinology
H MallucheR M Friedler

Abstract

The singular and combined effects of 1,25-dihydroxyvitamin D [1,25-(OH)2D] and PTH on bone were evaluated in a long term in vivo study in dogs. Dogs were rendered deficient in 1,25-(OH)2D and PTH by five sixths nephrectomy and parathyroidectomy. A control group was sham operated. Various combinations in status of 1,25-(OH)2D and PTH were produced by daily sc injections of 1,25-(OH)2D (1.25) and/or continuous infusion of 1-34 bovine PTH. These were 1.25+/PTH+, 1.25-/PTH-, 1.25+/PTH-, 1.25-/PTH+. Serum calcium levels were kept in the normal range by the administration of one or two of the hormones or by oral supplementation of calcium lactate. Histomorphometric evaluation of static and dynamic parameters of bone after 8 months of experimental observation revealed that deficiency in 1,25-(OH)2D and PTH resulted in decreased number and activity of bone-forming and resorbing cells. Administration of 1,25-(OH)2D increased the activity but not the number of bone cells. In contrast, administration of PTH increased the number but not the activity of bone cells. Tissue level activity was decreased when one or both hormones were deficient, and normal tissue level activity was found only when both hormones were given. These data are releva...Continue Reading

Citations

Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P FantiH H Malluche
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y TanakaY Nishii
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y IsogaiT Suda
Mar 1, 1992·Calcified Tissue International·R G ErbenH Zucker
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H H MallucheM C Monier-Faugere
Nov 15, 2002·Molecular and Cellular Endocrinology·H A W Hazewinkel, M A Tryfonidou
Jul 12, 2002·Kidney International·Hartmut H MallucheNicholas J Koszewski
Mar 1, 1987·The Journal of Clinical Investigation·H H MallucheP Fanti
Aug 1, 1990·Kidney International·H Malluche, M C Faugere
May 1, 1992·Kidney International·T H IttelH G Sieberth
Oct 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Enrico BaroniDaniele D'Ambrosio
Jul 15, 2003·Journal of Cellular Biochemistry·Sohei KitazawaRiko Kitazawa
Jun 30, 1987·Toxicology and Applied Pharmacology·M AndoM Takeda
Aug 4, 2006·European Journal of Clinical Investigation·H H MallucheH Mawad
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C H KasperkR Ziegler
Aug 8, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian

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