1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

The Journal of Steroid Biochemistry and Molecular Biology
M H Pourgholami, D L Morris

Abstract

1,25-Dihydroxyvitamin D(3) (1,25-(OH)(2) D(3)) is a potent regulator of cell growth and differentiation, with recent evidence showing inhibition of tumor invasion, angiogenesis and tumor cell death. The growth-inhibitory properties of 1,25-(OH)(2) D(3) could be harnessed in the treatment of patients with cancer if the development of systemic hypercalcemia is avoided. Hepatocellular cancer (HCC) presents a setting where the tumor is accessible for treatment through the hepatic artery and also where the tumor is highly lipiodol avid. On this basis, we hypothesised that, 1,25-(OH)(2) D(3) dissolved in lipiodol and administered through the hepatic artery may prove to be a rational approach to the use of the drug in the treatment of HCCs. In brief, 6 years of work with 1,25-(OH)(2) D(3) at cellular, animal and clinical level has provided us with plenty of support for this hypothesis. Sensitivity of HCCs in cell culture to 1,25-(OH)(2) D(3), growth retardation of human HCC xenografts in nude mice, uptake and retention of 1,25-(OH)(2) D(3)-lipiodol by liver tumors in cell culture and animals, escalation of the 1,25-(OH)(2) D(3) dose by 100x without the development of hypercalcemia in both liver tumor bearing rats and in patients with ...Continue Reading

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Citations

Jul 14, 2012·Molecular and Cellular Endocrinology·Michele VaccaAntonio Moschetta
Aug 31, 2010·Gastroentérologie Clinique Et Biologique·A RodeA Nicoll
Oct 21, 2005·Biochimica Et Biophysica Acta·Kent WehmeierArshag D Mooradian
Jan 12, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E V KugaevskayaN I Solovyeva

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