Abstract
1,25-Dihydroxyvitamin D(3) (1,25-(OH)(2) D(3)) is a potent regulator of cell growth and differentiation, with recent evidence showing inhibition of tumor invasion, angiogenesis and tumor cell death. The growth-inhibitory properties of 1,25-(OH)(2) D(3) could be harnessed in the treatment of patients with cancer if the development of systemic hypercalcemia is avoided. Hepatocellular cancer (HCC) presents a setting where the tumor is accessible for treatment through the hepatic artery and also where the tumor is highly lipiodol avid. On this basis, we hypothesised that, 1,25-(OH)(2) D(3) dissolved in lipiodol and administered through the hepatic artery may prove to be a rational approach to the use of the drug in the treatment of HCCs. In brief, 6 years of work with 1,25-(OH)(2) D(3) at cellular, animal and clinical level has provided us with plenty of support for this hypothesis. Sensitivity of HCCs in cell culture to 1,25-(OH)(2) D(3), growth retardation of human HCC xenografts in nude mice, uptake and retention of 1,25-(OH)(2) D(3)-lipiodol by liver tumors in cell culture and animals, escalation of the 1,25-(OH)(2) D(3) dose by 100x without the development of hypercalcemia in both liver tumor bearing rats and in patients with ...Continue Reading
References
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Konno
Aug 18, 1992·Biochemical Pharmacology·K W ColstonR C Coombes
Dec 15, 1992·Biochemical Pharmacology·K W ColstonR C Coombes
Feb 1, 1991·Radiology·O MatsuiM Ida
Nov 1, 1990·Cancer·T Konno
Mar 1, 1989·Journal of Cellular Physiology·J A EismanG Y Pang
Jan 1, 1985·Radiology·Y YumotoK Okuda
May 1, 1987·Cancer·J A RidgeJ M Daly
Dec 1, 1984·Cancer·T KonnoY Miyauchi
Dec 1, 1980·The Journal of Clinical Investigation·S NagubandiP S Tietz
Mar 1, 1981·Endocrinology·K ColstonD Feldman
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E AbeT Suda
Feb 1, 1980·The Journal of Clinical Investigation·R KumarJ M Londowski
Jan 14, 1998·Urology·R H GetzenbergC S Johnson
Jan 1, 1994·Cell Proliferation·J J GodynG P Studzinski
Mar 28, 2001·Cancer Chemotherapy and Pharmacology·K TabaruN Kitamura
May 8, 2001·Journal of Gastroenterology and Hepatology·I G FinlayD L Morris
Jul 14, 2001·ANZ Journal of Surgery·J AkhterD L Morris
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaT Konno
Mar 20, 2002·Current Drug Targets·G J C M van den Bemd, G T G Chang
Sep 18, 2002·Gut·P J Johnson
Citations
Aug 21, 2009·Genes and Immunity·Y-W HuangJ-H Kao
Jul 14, 2012·Molecular and Cellular Endocrinology·Michele VaccaAntonio Moschetta
Aug 31, 2010·Gastroentérologie Clinique Et Biologique·A RodeA Nicoll
Oct 21, 2005·Biochimica Et Biophysica Acta·Kent WehmeierArshag D Mooradian
May 24, 2007·Journal of Cellular Physiology·Edward GarayGeorge P Studzinski
Mar 31, 2005·Journal of Cellular Physiology·Qing WangGeorge P Studzinski
Feb 17, 2018·Nutrition & Metabolism·Shahida KhanNaheed Banu
Jan 12, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E V KugaevskayaN I Solovyeva