PMID: 3754600Jan 1, 1986Paper

1,25-Dihydroxyvitamin D3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20)

Journal of Steroid Biochemistry
C ChouvetS Saez

Abstract

1,25 (OH)2 D3 has been shown to be able to reduce the growth of several human cell lines. The effect of 1,25 (OH)2 D3 on the growth of breast cancer cell lines in relation to their oestrogen (ER) and progesterone (PGR) receptor content has been investigated. The growth inhibition of BT-20 and MCF-7 cell lines is related to the dose of 1,25 (OH)2 D3. It is dependent on the foetal calf serum concentration in the culture medium. At low concentration of 1,25 (OH)2 D3 the inhibitory effect is not detectable in the presence of 10% FCS. The rescue of cells from inhibition by serum was less effective when 1,25 (OH)2 D3 was present in the medium. The results of [3H]thymidine incorporation experiments and DNA measurements are in agreement with the reduction of cell number. Analysis in flow cytometry indicated a reduced number of cells in S phase. These data indicate that 1,25 (OH)2 D3 is able to modulate the growth of human breast adenocarcinoma cells regardless of their sex steroid dependency.

References

Aug 31, 1981·Biochemical and Biophysical Research Communications·H C FreakeI MacIntyre
Mar 1, 1984·Calcified Tissue International·S C ManolagasL J Deftos

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Citations

Feb 1, 1994·Breast Cancer Research and Treatment·T Vink-van WijngaardenJ P van Leeuwen
Jan 1, 1994·Breast Cancer Research and Treatment·S A Chrysogelos, R B Dickson
May 1, 1994·Clinical & Experimental Metastasis·C M HansenL Binderup
May 27, 2005·Cancer Chemotherapy and Pharmacology·Josephia R MuindiDonald L Trump
Oct 11, 2011·Cancer Causes & Control : CCC·Lusine YaghjyanBettina Drake
May 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Vink-van WijngaardenJ P van Leeuwen
Jul 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·M Simboli-CampbellJ Welsh
Nov 26, 1999·The Surgical Clinics of North America·A Jatoi, C L Loprinzi
Mar 20, 2003·Molecular and Cellular Endocrinology·Glendon M ZinserJoEllen Welsh
Oct 23, 1998·Molecular and Cellular Endocrinology·L VerlindenR Bouillon
Apr 15, 2000·Cancer Letters·M H PourgholamiD L Morris
Jan 1, 1997·Breast Cancer Research and Treatment·M Simboli-CampbellJ Welsh
Apr 16, 1998·Breast Cancer Research and Treatment·X YangJ M Voigt
Jun 26, 2004·Breast Cancer Research and Treatment·Kenneth R McGaffinSusan A Chrysogelos
Aug 14, 2002·The British Journal of Dermatology·J E Osborne, P E Hutchinson
Dec 5, 2008·The Journal of Biological Chemistry·Puneet DhawanSylvia Christakos
Oct 19, 2006·Journal of Clinical Pathology·C PalmieriD Vigushin
Dec 4, 2013·International Journal of Oncology·Mohammed I KhanCezary Szczylik
Mar 21, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Ivy ChungDonald L Trump
May 11, 2010·Molecular and Cellular Endocrinology·R KumarD F Callen
Mar 1, 1989·Differentiation; Research in Biological Diversity·L FrappartS Saez
Sep 5, 2003·Journal of Clinical Pharmacology·Josephia R MuindiDonald L Trump
Mar 5, 2011·Molecular Oncology·Sinead Field, Julia A Newton-Bishop
Apr 1, 1991·The British Journal of Surgery·P LointierS Saez
Oct 1, 1990·Journal of Cellular Physiology·N F GuilbaudA Valette
Jul 6, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Kari B WisinskiHoward H Bailey
Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P BortmanM M Brentani
Apr 15, 1991·Biochemical and Biophysical Research Communications·P Y DesprezS Saez
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Glendon M Zinser, JoEllen Welsh

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