1,25-Dihydroxyvitamin D3 inhibits the passive transfer of cellular immunity by a myelin basic protein-specific T cell clone

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
J M Lemire, J S Adams

Abstract

1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] and related analogs have been shown to exert immunoinhibitory effects on activated lymphocytes in vitro. However, the effects of the hormone on the mammalian immune response in vivo have not been well studied. To examine the possible immunoactions of 1,25-(OH)2D3 in vivo, we employed a murine model of experimental autoimmune encephalomyelitis (EAE). In this model, T helper lymphocyte clones developed from lines of lymphocytes reactive to myelin basic protein (MBP) confer MBP immunoreactivity and demyelinating central nervous system disease on syngeneic, naive recipients of the T cell clone. Similar to peripheral blood mononuclear cells incubated with mitogen, the T cell clone evaluated in this study expressed a high-affinity specific receptor for 1,25-(OH)2D3 (VDR; K(in) = 0.03 nM) upon exposure to MBP. The MBP-stimulated clone elicited a ninefold enhancement of the local delayed hypersensitivity (DTH) response when as few as 0.5 x 10(5) cells of the T cell clone were injected into the foot pad of recipient mice. The DTH response in the recipient was completely blocked when the clone was preincubated with greater than or equal to 10(-8) M 1,25-(OH)2D3 before transfer; the half-maximal inh...Continue Reading

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Citations

Jul 25, 2012·Critical Reviews in Food Science and Nutrition·Swui-Ling HoAtif B Awad
Mar 26, 2003·Annual Review of Nutrition·Matthew D GriffinRajiv Kumar
Jul 18, 2014·Annual Review of Nutrition·Natalie J GrovesThomas H J Burne
Aug 21, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wen-Chih LiuKuo-Cheng Lu
Oct 25, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Abigail Basson
May 1, 1992·Journal of Cellular Biochemistry·J M Lemire
Feb 26, 2011·Nature Reviews. Immunology·Polly Matzinger, Tirumalai Kamala
Mar 17, 2000·Proceedings of the Society for Experimental Biology and Medicine·M T Cantorna
Apr 1, 2004·European Journal of Clinical Nutrition·B M VanAmerongenC H Polman

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