1,25-Dihydroxyvitamin D3 treatment results in increased choline acetyltransferase activity in specific brain nuclei

Endocrinology
J SonnenbergS Christakos

Abstract

To better understand the role of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in brain function, the level of calcium-binding protein (CaBP) and the activities of choline acetyltransferase (CAT) and monoamine oxidase were measured in discrete brain nuclei of vitamin D-deficient and -replete male rats. The nuclei sampled were those in which receptors for 1,25-(OH)2D3 and/or vitamin D-dependent CaBP have been localized. Significant elevations in CAT activity were found in the arcuatemedian eminence and in the bed nucleus of the stria terminalis of rats made vitamin D replete by eight daily ip injections of 100 or 200 ng 1,25-(OH)2D3 as well as by constant intraventricular (ivi) infusion of 25 ng 1,25-(OH)2D3 for 7 days. The percent increase ranged from 12-45% and was related to the ip dose administered. Constant ivi of 2 mM CA2+ or 125 ng 25-hydroxyvitamin D3/day for 7 days did not alter CAT activity. No significant changes in monoamine oxidase or CaBP in discrete brain nuclei were observed with vitamin D repletion. Since the arcuate-median eminence of the hypothalamus is an important regulatory site in the neuroendocrine control of reproduction, serum testosterone was measured. Serum testosterone levels were abnormally low in the vit...Continue Reading

Citations

Dec 1, 1996·Journal of Neuroscience Research·C BaudetD Wion
Sep 30, 1998·Journal of Neuroscience Research·A CornetP Naveilhan
Jan 1, 1991·Journal of Neuroscience Research·D WionP Brachet
Jan 1, 1987·Histochemistry·W E Stumpf, L P O'Brien
Dec 1, 1994·Psychopharmacology·D A OrenN E Rosenthal
Oct 14, 2011·European Archives of Psychiatry and Clinical Neuroscience·H Y JaddouK M Ajlouni
Mar 24, 1992·European Journal of Pharmacology·M R WaltersS Christakos
Jan 1, 1987·Physiology & Behavior·K L AltemusS J Birge
Jul 1, 1994·Brain Research. Molecular Brain Research·I NeveuP Brachet
May 1, 1994·Brain Research. Molecular Brain Research·C Quirin-StrickerM Schmitt
Feb 5, 1996·Molecular and Cellular Endocrinology·F JehanD Wion
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·W E Stumpf, T H Privette
Oct 31, 1997·The American Journal of Medicine·S J Birge, K F Mortel
Apr 20, 2001·Neuroscience·M C LangubN J Koszewski
Jul 18, 2001·The Journal of Steroid Biochemistry and Molecular Biology·M StioC Treves
Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Emmanuel GarcionDidier Wion
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P A de ViraghM R Celio
May 27, 2008·Dementia and Geriatric Cognitive Disorders·C OudshoornT J M van der Cammen
Dec 14, 2011·Neuroepidemiology·Cédric Annweiler, Olivier Beauchet
Sep 26, 2012·Neurology·Cynthia BalionParminder Raina
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J K DhesiT J Allain
May 29, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Martin Blomberg Jensen
Jan 15, 2014·Nature Reviews. Endocrinology·Martin Blomberg Jensen
Jul 18, 2014·Annual Review of Nutrition·Natalie J GrovesThomas H J Burne
Oct 23, 2010·The International Journal of Neuroscience·Mohsen TaghizadehSayyed Alireza Talaei Zavareh
May 2, 2003·Expert Opinion on Investigational Drugs·Mark S Stein, John D Wark
Jun 8, 2013·Pharmacological Reports : PR·Małgorzata WrzosekGrażyna Nowicka
Nov 1, 1989·American Journal of Obstetrics and Gynecology·W E Stumpf, M E Denny
Jun 1, 1994·Journal of Neuroscience Research·I NeveuM Garabédian
Feb 22, 2012·Archives of Biochemistry and Biophysics·Neil Binkley
Aug 31, 2010·Journal of Photochemistry and Photobiology. B, Biology·Mats B Humble

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.