1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

Proceedings of the National Academy of Sciences of the United States of America
M StromHector F DeLuca

Abstract

The level of mRNA encoding the 1,25-dihydroxyvitamin D3 receptor in the intestine of vitamin D-deficient rats given 1,25-dihydroxyvitamin D3 was determined by Northern blot analysis using a 32P-labeled cDNA probe to the 1,25-dihydroxyvitamin D3 receptor. mRNA levels increased 10-fold above deficiency levels at 6 and 12 hr after an intravenous dose of 1,25-dihydroxyvitamin D3, returning to predosing levels at 24 hr. Total receptor protein level determined by an immunoradiometric assay was increased 2-fold at 12 hr. No change in unoccupied receptor levels determined by ligand-binding assay was observed during this period. These results suggest that 1,25-dihydroxyvitamin D3 increases receptor mRNA and total receptor level to maintain constant levels of unoccupied receptor.

Associated Clinical Trials

Aug 25, 2017·Donald Trump, MD, Donald Trump, MD

References

Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J K BurmesterH F DeLuca
Mar 1, 1988·Archives of Biochemistry and Biophysics·E A Pierce, H F DeLuca
Jun 13, 1986·Biochemical and Biophysical Research Communications·E M Costa, D Feldman
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Jan 1, 1983·Annual Review of Biochemistry·H F DeLuca, H K Schnoes

❮ Previous
Next ❯

Citations

Aug 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N MayurM S Nanes
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S SriussadapornM J Favus
Nov 1, 1994·Journal of Cellular Biochemistry·C P WhiteJ A Eisman
Apr 16, 1993·Biochimica Et Biophysica Acta·A Uhland-Smith, H F DeLuca
Jul 1, 1994·Brain Research. Molecular Brain Research·I NeveuP Brachet
Jan 1, 1993·Molecular and Cellular Endocrinology·R J WieseH F DeLuca
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M T EscaleiraM M Brentani
Aug 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·F DavoodiR R Buras
Mar 4, 1998·Mechanisms of Ageing and Development·C ChenD N Kalu
Sep 17, 2002·Urology·Candace S JohnsonDonald L Trump
Jan 3, 1997·Molecular and Cellular Endocrinology·J Xu, H L Henry
Jul 26, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Simon Skjøde JensenLise Binderup
Dec 12, 2012·The British Journal of Nutrition·Priyanka ShankarArjun L Khandare
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M E Sandgren, H F DeLuca
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·X P YuS C Manolagas
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·D A Bushinsky
Jun 16, 2006·Current Opinion in Nephrology and Hypertension·David A BushinskyKeith Nehrke
Apr 29, 1998·Pharmacology & Toxicology·C HemmingsenK Olgaard
Jun 8, 2012·BMC Cancer·Christoph RennéMartin L Hansmann
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R C GensureM R Walters
Mar 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Indra Ramasamy
Apr 25, 2000·Biochemical and Biophysical Research Communications·W LutzR Kumar
Dec 7, 2007·Biogerontology·Verónica González PardoAna Russo de Boland
Oct 31, 1991·Biochemical and Biophysical Research Communications·R C GensureM R Walters
Sep 1, 1994·Kidney International·C H HsuR Vanholder
Mar 27, 2010·General and Comparative Endocrinology·Pia Bagamasbad, Robert J Denver
Dec 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ansar A KhanGeny M M Groothuis
Sep 27, 2003·Biochemical and Biophysical Research Communications·Kensei YahataKazuwa Nakao
Apr 1, 1993·Kidney International·A J Felsenfeld, F Llach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.