PMID: 8611350Feb 1, 1996Paper

125Iodine-iothalamate clearance in children. A simple method to measure glomerular filtration

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
G BajajM G Seikaly

Abstract

Glomerular filtration rate (GFR) is the most widely used test to evaluate renal function. Several clearance markers have been used to measure GFR in adults. In children, however, a simple and reliable method to measure GFR is not available. Renal 125iodine (I)-iothalamate clearance, after a single subcutaneous injection, is a simple and accurate test to measure GFR in adults. The validity of unlabelled iothalamate, as a marker for measurement of GFR in children, was reported recently. Unfortunately, the unlabelled iothalamate assay is arduous. We report our experience with a single subcutaneous injection of 125I-iothalamate to measure GFR in normal children and those with renal disease. A weight-adjusted dosing regimen was adopted. This regimen resulted in sufficient above-background radioactivity in both blood and urine for reproducible measurement of GFR. Intra-test variability for GFR was not affected by the degree of renal insufficiency. The test was well tolerated with only 2 patients developing mild headache during the procedure. Our study showed that renal clearance of 125I-iothalamate is reproducible, simple, and practical in healthy children and those with mild and advanced renal disease.

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Citations

Oct 15, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Karen E PapezBruce Z Morgenstern
Jul 26, 2012·International Journal of Pediatrics·Raymond Quigley
Nov 28, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Khurrum SiddiqueMouin G Seikaly
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Emilio D PoggioPhillip M Hall
Jan 9, 2008·Pediatric Transplantation·Guido Filler, Ajay P Sharma
Nov 4, 2005·Journal of Neurosurgery. Spine·Jorge E Collazos-CastroManuel Nieto-Sampedro
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George J Schwartz, Dana F Work
Sep 30, 2010·Journal of Biomaterials Applications·Eduardo Martín-LópezManuel Nieto-Sampedro
Oct 25, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Guido FillerAbeer Yasin
Jan 20, 1998·Developmental Medicine and Child Neurology·A QuanM Baum

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