1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes

The Journal of Clinical Investigation
J WuD G Gardner

Abstract

1,25(OH)2 Vitamin D3 (VD3) and retinoic acid (RA) function as ligands for nuclear receptors which regulate transcription. Though the cardiovascular system is not thought to represent a classical target for these ligands, it is clear that both cardiac myocytes and vascular smooth muscle cells respond to these agents with changes in growth characteristics and gene expression. In this study we demonstrate that each of these ligands suppresses many of the phenotypic correlates of endothelin-induced hypertrophy in a cultured neonatal rat cardiac ventriculocyte model. Each of these agents reduced endothelin-stimulated ANP secretion in a dose-dependent fashion and the two in combination proved to be more effective than either agent used alone (VD3: 49%; RA:52%; VD3 + RA:80% inhibition). RA, at concentrations known to activate the retinoid X receptor, and, to a lesser extent, VD3 effected a reduction in atrial natriuretic peptide, brain natriuretic peptide, and alpha-skeletal actin mRNA levels. Similar inhibition (VD3:30%; RA:33%; VD3 + RA:59% inhibition) was demonstrated when cells transfected with reporter constructs harboring the relevant promoter sequences were treated with VD3 and/or RA for 48 h. These effects were not accompanied...Continue Reading

Associated Clinical Trials

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerR M Evans
Jun 11, 1991·The Journal of Clinical Investigation·T MitsuhashiH E Ives
Dec 15, 1989·Biochemical and Biophysical Research Communications·J J SeilhamerJ G Porter
Dec 17, 1987·Nature·V GiguereR M Evans
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Jan 1, 1986·Journal of Molecular and Cellular Cardiology·M R WaltersP C Riggle
Jun 1, 1987·The Journal of Clinical Investigation·R E Weishaar, R U Simpson
Oct 1, 1987·The Journal of Cell Biology·J A Cooper
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·E DysonK R Chien
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·M D ZhouK R Chien

❮ Previous
Next ❯

Citations

Nov 8, 2005·Basic Research in Cardiology·Christophe MontessuitRené Lerch
Dec 15, 2006·Cardiovascular Research·Naveen SharmaWilliam C Stanley
Nov 26, 1999·Life Sciences·D G Gardner, S Chen
Jun 13, 2001·Journal of the American College of Cardiology·K K WitteJ G Cleland
Oct 29, 2003·Trends in Endocrinology and Metabolism : TEM·David G Gardner
Nov 1, 1997·Trends in Cardiovascular Medicine·S M Smith, E D Dickman
Aug 5, 1999·Kidney International·S G Rostand, T B Drüeke
Jun 12, 2013·European Heart Journal·Ibhar Al MheidArshed A Quyyumi
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tetsuo ShojiYoshiki Nishizawa
Oct 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadezda KoleganovaMarie-Luise Gross
Nov 11, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Armando L Negri
Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge Rojas-RiveraJesús Egido
Sep 10, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sara PanizoJorge B Cannata-Andía
Jun 3, 2005·Current Opinion in Nephrology and Hypertension·Tilman B Drüeke
Jan 26, 2010·Transplantation·Marie CourbebaisseEric Thervet
Dec 1, 2005·Kidney International·Rajiv AgarwalDaniel Batlle
Sep 4, 2008·Seminars in Dialysis·Maurizio BossolaGiovanna Luciani
Oct 5, 2011·Seminars in Dialysis·James Goya HeafPeter Marckmann
Oct 22, 2008·Hypertension·Songcang ChenDavid G Gardner
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Jan 1, 2008·International Journal of Nephrology and Renovascular Disease·James B Wetmore, L Darryl Quarles
Feb 26, 2011·Nutrients·Diana N D'AmbrosioWilliam S Blaner
Oct 15, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Piergiorgio MessaCarlo Maria Alfieri
Jun 24, 2010·Journal des maladies vasculaires·C CormierJ-C Souberbielle
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M N SackD P Kelly
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natalya BodyakPeter M Kang
Jan 1, 2013·ISRN Nephrology·Yu-Hsien Lai, Te-Chao Fang
Jul 16, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Daniel-Constantin ManolescuJolanta Gutkowska
Jan 1, 2014·Journal of Clinical Medicine·Jing PanKenneth M Baker
Mar 21, 2007·Expert Opinion on Investigational Drugs·Jinshyun Ruth Wu-Wong
Oct 16, 2013·Journal of Cardiac Failure·Anna J Meredith, Bruce M McManus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Natalya BodyakPeter M Kang
Proceedings of the National Academy of Sciences of the United States of America
M D ZhouK R Chien
© 2021 Meta ULC. All rights reserved