1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine.

The Journal of Physiology
Nati HernandoCarsten A Wagner

Abstract

Intestinal absorption of phosphate proceeds via an active/transcellular route mostly mediated by NaPi-IIb/Slc34a2 and a poorly characterized passive/paracellular pathway. Intestinal phosphate absorption and expression of NaPi-IIb are stimulated by 1,25(OH)2 vitamin D3 but whether NaPi-IIb is the only target under hormonal control remains unknown. We report that administration of 1,25(OH)2 vitamin D3 to wild-type mice resulted in the expected increase in active transport of phosphate in jejunum, without changing paracellular fluxes. Instead, the same treatment failed to alter phosphate transport in intestinal-depleted Slc34a2-deficient mice. In both genotypes, 1,25(OH)2 vitamin D3 induced similar hyperphosphaturic responses and changes in the plasma levels of FGF23 and PTH. While urinary phosphate loss induced by administration of 1,25(OH)2 vitamin D3 did not alter plasma phosphate, further studies should investigate whether chronic administration would lead to phosphate imbalance in mice with reduced active intestinal absorption. Intestinal absorption of phosphate is stimulated by 1,25(OH)2 vitamin D3. At least two distinct mechanisms underlie phosphate absorption in the gut, an active transcellular transport requiring the Na+ ...Continue Reading

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Citations

Dec 10, 2020·The Journal of Physiology·R Todd Alexander
Jan 21, 2021·International Journal of Molecular Sciences·Joie L BehrensAlexandra S Muscher-Banse
Apr 14, 2021·Scientific Reports·Eva Maria Pastor-ArroyoCarsten A Wagner
May 25, 2021·Current Opinion in Nephrology and Hypertension·Kathleen M Hill Gallant, Colby J Vorland
Jun 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rocío FuenteIsabel Rubio-Aliaga
Aug 1, 2021·Journal of the American Society of Nephrology : JASN·Kittrawee Kritmetapak, Rajiv Kumar

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