12(S)-HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis

Biochemical and Biophysical Research Communications
D G TangK V Honn

Abstract

12(S)-HETE [12(S)-hydroxyeicosatetraenoic acid] is a lipoxygenase metabolite of arachidonic acid. Treatment of murine-lung-derived microvascular endothelial cells (CD clone 4) with exogenous 12(S)-HETE promoted wound healing of injured endothelial cell monolayers. 12(S)-HETE, in a time- and dose-dependent manner, enhanced the growth of CD clone 4 cells. Thymidine incorporation assays demonstrated that 12(S)-HETE increased the DNA synthesis by > 4 fold. In addition, normal endothelial cell growth stimulated by serum could be dose-dependently inhibited by a select 12-lipoxygenase inhibitor (BHPP), suggesting that 12(S)-HETE is a physiological mitogenic factor for microvascular endothelial cells.

Citations

Oct 18, 2011·Cancer Metastasis Reviews·Claus Schneider, Ambra Pozzi
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D G TangK V Honn
Apr 30, 2003·Antioxidants & Redox Signaling·Valerie B O'Donnell
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yuttana ChawengsubWilliam B Campbell
May 30, 2002·Biological Chemistry·Dean G TangJames P Kehrer
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Ghosh, C E Myers
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y KurahashiS Hammarström
Jan 6, 2001·Nutrition and Cancer·D P Rose, J M Connolly
Nov 4, 2000·Expert Opinion on Investigational Drugs·V E SteeleG J Kelloff
Dec 11, 1999·Cancer Investigation·M E Beckner
Jan 27, 2004·The American Journal of Pathology·Daotai NieKenneth V Honn
May 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kai-Hsiang KangWen-Mei Fu
Oct 9, 2003·The Journal of Urology·Rikio YoshimuraTatsuya Nakatani
Mar 26, 2013·International Journal of Cancer. Journal International Du Cancer·Ashok-kumar DillyKenneth V Honn
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ambra Pozzi, Roy Zent
Feb 7, 2001·Cancer Letters·M Mukutmoni-NorrisK L Erickson
Sep 19, 2006·Journal of Lipid Research·Diana Nieves, Juan José Moreno
Aug 5, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ahmad HanifMohammed A Nayeem
Jun 16, 2004·International Journal of Cancer. Journal International Du Cancer·Hung PhamVincent A Ziboh
Jun 8, 2018·Acta Pharmacologica Sinica·Mohammed A Nayeem
Mar 18, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·David T BolickCatherine C Hedrick
Mar 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Geun-Young KimJae-Hong Kim
Oct 19, 2007·Cancer Metastasis Reviews·Graham P PidgeonKenneth V Honn
Jan 1, 1996·Pathology Oncology Research : POR·Dean G Tang, Arthur T Porter
May 8, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bruce I Gaynes, Richard Fiscella
Oct 4, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ioana R PrestonBarry L Fanburg
Mar 28, 1998·Breast Cancer Research and Treatment·D P Rose, J M Connolly
Apr 28, 2006·The Journal of Biological Chemistry·Daotai NieKenneth V Honn
Jun 1, 2013·Expert Review of Ophthalmology·Mohamed Al-ShabraweyAmany Tawfik
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sandra L AmaralAndrew S Greene
Jun 18, 2020·Antioxidants·Mong-Heng WangMohamed Al-Shabrawey
May 20, 2000·Annals of the New York Academy of Sciences·D NieK V Honn

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