journal cover

13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor

Proceedings of the National Academy of Sciences of the United States of America

Aug 1, 1979

G C Le BretonP V Halushka

PMID: 291066

Abstract

A newly synthesized 13-aza derivative of prostanoic acid (13-APA) specifically inhibited human platelet aggregation induced by arachidonic acid, prostaglandin H2, or the stable endoperoxide analog (15S)-hydroxy-9 alpha,11 alpha-)epoxymethano)-prosta-5Z,13E-dienoic acid. 13-APA also inhi...read more

Mentioned in this Paper

Platelet Aggregation Measurement
Arachidonic Acid
13-azaprostanoic acid
Antagonist Muscle Action
Aggregation
F2 gene
Thrombin
Receptors, Drug
Saturated Fat
Prostaglandin Endoperoxides
Paper Details
References
  • References37
  • Citations75
1234
  • References37
  • Citations75
12345...

Feeds With Similar Papers

Platelet Activation

Platelets are a blood cell that can initiate clot formation in response to damage to blood vessels. Following platelet adhesion, platelets become activated before aggregating. Find the latest research on platelet activation here.

© 2020 Meta ULC. All rights reserved

13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor

Proceedings of the National Academy of Sciences of the United States of America

Aug 1, 1979

G C Le BretonP V Halushka

PMID: 291066

DOI:

Abstract

A newly synthesized 13-aza derivative of prostanoic acid (13-APA) specifically inhibited human platelet aggregation induced by arachidonic acid, prostaglandin H2, or the stable endoperoxide analog (15S)-hydroxy-9 alpha,11 alpha-)epoxymethano)-prosta-5Z,13E-dienoic acid. 13-APA also inhi...read more

Mentioned in this Paper

Platelet Aggregation Measurement
Arachidonic Acid
13-azaprostanoic acid
Antagonist Muscle Action
Aggregation
F2 gene
Thrombin
Receptors, Drug
Saturated Fat
Prostaglandin Endoperoxides

Feeds With Similar Papers

Platelet Activation

Platelets are a blood cell that can initiate clot formation in response to damage to blood vessels. Following platelet adhesion, platelets become activated before aggregating. Find the latest research on platelet activation here.

Related Papers

Paper Details
References
  • References37
  • Citations75
1234
  • References37
  • Citations75
12345...

Download from

PubMed
/papers/13-azaprostanoic-acid-a-specific-antagonist-of/291066