1,3-Butadiene, styrene and lymphohematopoietic cancer among male synthetic rubber industry workers--Preliminary exposure-response analyses

Chemico-biological Interactions
Nalini SathiakumarE Delzell

Abstract

We updated the mortality experience of North American synthetic rubber industry workers to include follow-up from 1944 through 2009, adding 11 years of mortality data to previous investigations. The present analysis used Cox regression to examine the exposure-response relationship between 1,3-butadiene (BD) and styrene (STY) parts per million (ppm)-years and leukemia (N = 114 deaths), non-Hodgkin lymphoma (NHL) (N = 89) and multiple myeloma (MM) (N = 48). A pattern of largely monotonically increasing rate ratios across deciles of BD ppm-years and a positive, statistically significant exposure-response trend were observed for BD ppm-years and leukemia. Using continuous, untransformed BD ppm-years the regression coefficient (β) adjusted only for age was 2.6 × 10(-4) (p < 0.01); the regression coefficient adjusted for age, year of birth, race and plant was 2.9 × 10(-4) (p < 0.01). STY ppm-years also displayed a positive exposure-response association with leukemia. STY and BD were strongly correlated, and the separate effects of these two agents could not be estimated. For NHL, a pattern of approximately monotonically increasing rate ratios across deciles of exposure was seen for STY but not for BD; the test of trend was statistica...Continue Reading

References

Jan 1, 1976·Annals of the New York Academy of Sciences·A J McMichaelH A Tyroler
Oct 1, 1992·American Journal of Epidemiology·C Santos-BurgoaL Schwartz
Jun 1, 1992·Scandinavian Journal of Work, Environment & Health·G G BondR R Cook
Oct 1, 1985·Scandinavian Journal of Work, Environment & Health·J T Hodgson, R D Jones
Jun 1, 1995·Environmental Health Perspectives·E M WardC A Fessler-Flesch
Aug 1, 1994·Scandinavian Journal of Work, Environment & Health·M KogevinasI Lundberg
Aug 1, 1994·Scandinavian Journal of Work, Environment & Health·H A KolstadN Breum
Jan 1, 1994·Critical Reviews in Toxicology·D Coggon
Oct 28, 1996·Toxicology·E DelzellD C Muir
Jun 13, 1998·Occupational and Environmental Medicine·N SathiakumarD C Muir
Jun 9, 2001·Chemico-biological Interactions·B J Divine, C M Hartman
Aug 26, 2003·Scandinavian Journal of Work, Environment & Health·Leslie StaynerIrva Hertz-Picciotto
Oct 13, 2004·Occupational and Environmental Medicine·D B Richardson, D Loomis
Feb 23, 2005·Occupational and Environmental Medicine·K Steenland
Sep 13, 2005·Journal of Occupational and Environmental Medicine·John J GraffElizabeth Delzell
Nov 22, 2005·Occupational and Environmental Medicine·N SathiakumarE Delzell
Aug 30, 2007·The Lancet Oncology·Yann GrosseUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Oct 28, 2009·Journal of Occupational and Environmental Medicine·Paolo BoffettaJack S Mandel
Dec 10, 2009·The Lancet Oncology·Robert BaanUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Jul 5, 2011·Mutagenesis·James Huff, Peter F Infante
Nov 2, 2014·Occupational and Environmental Medicine·David CoggonKeith T Palmer

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Citations

Mar 29, 2018·Critical Reviews in Toxicology·James J Collins, Elizabeth Delzell
Mar 14, 2018·Epidemiology·Mette Skovgaard ChristensenHenrik Albert Kolstad
May 8, 2018·Occupational and Environmental Medicine·Claire Marant MicallefIsabelle Soerjomataram
Mar 30, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Harvey CheckowayKenneth A Mundt
Aug 30, 2019·Journal of Occupational and Environmental Medicine·Nalini SathiakumarElizabeth Delzell
Jun 5, 2017·International Archives of Occupational and Environmental Health·Pernilla AlmerudG Sallsten
May 21, 2020·Environmental Health : a Global Access Science Source·Calvin JephcoteAlice Mah
Jul 10, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M I BantonS S Sarang

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