PMID: 8601741Feb 1, 1996Paper

13-cis-Retinoic acid affect sheath-shaft interaction of equine hair follicles in vitro

The Journal of Investigative Dermatology
D WilliamsK Stenn

Abstract

A major challenge to the study of hair follicle growth is an appropriate assay system. Because equine mane follicles are large and noncurved, enabling easy dissection; are readily accessible from a single defined source; and possess a long anagen growth phase, we initiated a study of them in culture. As in our previous studies of human and sheep follicles (Dev Biol 165:469, 1994), we found in this system that transection level dictates the pattern of follicle growth in vitro: follicles transected below the sebaceous gland show a type 1 growth pattern (the shaft grows out with an adherent sheath), while nontransected follicles show a type 2 growth pattern (a naked shaft grows out lacking a sheath). In the present study, we searched for compounds that might influence type 1 or type 2 patterns of growth. We found that 13-cis retinoic acid induced, in a concentration-dependent fashion, a type 1-like pattern of growth under conditions for which a type 2 pattern was expected. All-trans-retinoic acid, SR11237 (a synthetic retinoid X receptor-specific ligand), and meta-carboxy-TTNPB (and inactive synthetic retinoid) did not have these properties. We hypothesize that sheath growth¿processing is mediated by the follicle at the level of t...Continue Reading

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Citations

Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
Sep 4, 2012·Archives of Pharmacal Research·Sang-Cheol KimHee-Kyoung Kang
Feb 17, 2015·Experimental Dermatology·Marlon R Schneider
Oct 22, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·C B RobiaE Bamberg
Mar 1, 2011·Expert Opinion on Drug Discovery·Ajay SemaltyMohan Singh Maniyari Rawat
Nov 1, 2007·The British Journal of Dermatology·M BlountP Slusarewicz
Dec 18, 2013·Veterinary Dermatology·Jeanine Peters-KennedyWilliam H Miller
Jun 9, 2001·Clinics in Dermatology·G E Rogers, P I Hynd
Sep 21, 2001·The Journal of Investigative Dermatology·M RobinsonC A Jahoda

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