13-cis Retinoic acid ameliorates benzoyl peroxide-induced oxidative stress and hyperproliferative response in murine skin: a chemopreventive study

Cancer Detection and Prevention
Sarwat SultanaNaghma Khan

Abstract

The present paper assesses the chemopreventive potential of retinoic acid on benzoyl peroxide (BPO)-induced cutaneous tumor promotion response and oxidative stress in murine skin. In this study, we have shown the activities of cutaneous antioxidant enzymes and phase II metabolizing enzymes and the glutathione content were decreased while epidermal ornithine decarboxylase (ODC) activity and DNA synthesis were induced in benzoyl peroxide treated animals. Topical application of retinoic acid resulted in significant inhibition of benzoyl peroxide-induced epidermal ornithine decarboxylase activity and DNA synthesis. Application of retinoic acid at three different doses prior to the application of benzoyl peroxide recovered the depleted level of glutathione, inhibited activities of antioxidant and phase II metabolizing enzymes, thus resulting in significant inhibition of oxidative stress in dose dependent manner. Enhanced susceptibility of cutaneous microsomal lipid peroxidation and xanthine oxidase activity were significantly reduced (P > 0.05). The antimutagenic effect of retinoic acid was tested against benzoyl peroxide mediated mutagenicity in Salmonella typhimurium strain TA-98 and TA-100 using 3-methyl cholanthrene-induced muri...Continue Reading

References

Jan 1, 1990·Free Radical Biology & Medicine·Y Sun
Sep 20, 1990·The New England Journal of Medicine·W K HongL J Peters
Oct 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S GarewalK Steinbronn
Jan 1, 1990·Free Radical Biology & Medicine·V M Samokyszyn, L J Marnett
Jan 1, 1989·Pharmacology & Therapeutics·S M Lippman, F L Meyskens
Jan 1, 1989·Free Radical Biology & Medicine·J P Perchellet, E M Perchellet
Jan 1, 1989·Free Radical Biology & Medicine·N I Krinsky
Aug 1, 1988·Journal of Cellular Physiology·M ShibanumaK Nose
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·H F StichM K Nair
Dec 11, 1986·The New England Journal of Medicine·W K HongC Vaughan
May 1, 1983·Mutation Research·D M Maron, B N Ames
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M BensonP Talalay
Feb 1, 1981·Archives of Biochemistry and Biophysics·J R WrightP R Miles
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·A E PeggC S Coleman
Feb 5, 2000·Seminars in Surgical Oncology·F R Khuri, S M Lippman
Mar 1, 1965·Archives of Biochemistry and Biophysics·N ZAHEERP S KRISHNAN

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