Abstract
Herein, folic acid (FA) conjugated Poly(d,l-lactide-co-glycolide) (PLGA)-lipid composites (FA-PL) were developed as nanocarriers for the targeted delivery of insoluble anti-cancer drug paclitaxel (PTX), resulting FA-PLP nanoparticles. Furthermore, (131)I, as a radioactive tracer, was used to label FA-PLP nanoparticles (FA-PLP-(131)I) to evaluate their cell uptake activity, in vivo blood circulation, and biodistribution. The FA-PLP-(131)I nanoparticles had a spherical morphology with great stability, a narrow size distribution (165.6 and 181.2 nm), and -22.1 mV in average zeta potential. Confocal laser scanning microscopy indicated that the targeting molecule FA promotes PLP-(131)I uptake by melanoma B16F10 cells, which was further confirmed by the cell incorporation rate via (131)I activity detection as measured by a gamma counter. FA-PLP-(131)I without PTX (FA-PL-(131)I) shows minor cytotoxicity, good biocompatibility, while FA-PLP-(131)I was demonstrated to have efficient cell viability suppression compared to free PTX and PLP-(131)I. Following intravenous injection, the blood circulation half-life of free PTX (t 1/2 = 5.4 ± 0.23 h) was prolonged to 18.5 ± 0.5 h by FA-PLP-(131)I. Through FA targeting, the tumor uptake of FA-P...Continue Reading
References
Mar 5, 1998·Journal of the National Cancer Institute·J SzebeniC R Alving
Apr 20, 2004·Advanced Drug Delivery Reviews·Chrystal M PaulosPhilip S Low
Apr 1, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Perihan Unak, Berkan Cetinkaya
Aug 15, 2008·Cancer Research·Zhuang LiuHongjie Dai
Mar 23, 2010·Advanced Drug Delivery Reviews·Vladimir Torchilin
Jan 1, 2009·OncoTargets and Therapy·Francesco Di CostanzoFederica Di Costanzo
Aug 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Apr 20, 2011·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Moorthi ChidambaramK Kathiresan
Dec 16, 2011·Biomaterials·Kai YangZhuang Liu
Feb 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Jan 15, 2013·Pharmaceutical Research·Sneha A Kulkarni, Si-Shen Feng
Jun 15, 2013·The Journal of Dermatological Treatment·Chelsea Ma, April W Armstrong
Aug 21, 2013·The Lancet Oncology·Noriyuki KatsumataUNKNOWN Japanese Gynecologic Oncology Group
Mar 13, 2014·International Journal of Pharmaceutics·Daniela SmejkalováVladimír Velebný
May 6, 2014·Biomaterials·Shixian LvXuesi Chen
Sep 13, 2014·ACS Applied Materials & Interfaces·Zhiyuan XuXiaoyu Huang
Dec 3, 2014·Cancer Letters·Tommaso AzzaritoStefano Fais
Jan 30, 2015·Journal of the American Chemical Society·Fuwu ZhangKaren L Wooley
Mar 31, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Edgar Pérez-Herrero, Alberto Fernández-Medarde
Aug 27, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Melissa A WilsonKatherine L Nathanson
Apr 30, 2016·Nature Reviews. Cancer·A Hunter Shain, Boris C Bastian
Nov 9, 2016·OncoTargets and Therapy·Kazutoshi KomiyaNaoko Sueoka-Aragane
Nov 18, 2016·International Journal of Nanomedicine·Yu XinChenlong Yang
Dec 25, 2016·Brain Research·Jingmei GaoJian Tan
Jan 25, 2017·Nanoscale Research Letters·Tieliang WangChao Wu
Citations
Sep 8, 2019·Nanoscale Research Letters·Qingkai ZhengZhongdong Li
Oct 13, 2018·Nanoscale Research Letters·Hainan YangHui Lian
Apr 18, 2020·Frontiers in Oncology·Lingling SiYing Liu
Aug 11, 2018·Journal of Cancer Research and Clinical Oncology·Harshita MishraSushama Talegaonkar
Sep 18, 2020·Advances in Colloid and Interface Science·Aoxue ZhangShuyu Xie
Apr 27, 2021·Nanotoxicology·Marcel F Kunrath, Maria M Campos