1,3,5,6-Tetrahydroxyxanthone, a natural xanthone, induces diuresis and saluresis in normotensive and hypertensive rats

Chemico-biological Interactions
Luísa Nathália Bolda MarianoSergio Faloni de Andrade

Abstract

The aim of the present study was to evaluate the diuretic effect of 1,3,5,6-tetrahydroxyxanthone (THX), isolated from preparations of Garcinia achachairu Rusby (Clusiaceae) branches, in rats. Wistar normotensive (NTR) and spontaneously hypertensive rats (SHR) received a single oral treatment with THX, hydrochlorothiazide (HCTZ) or just vehicle (VEH). The effects of THX in combination with diuretics of clinical use, as well as with l-NAME, atropine, and indomethacin were also explored. Cumulative urine volume and urinary parameters were measured at the end of the 8-h or 24-h experiment. THX was able to stimulate 8-h and 24-h diuresis in both NTR and SHR, as well as urinary Na+ and K+ excretion, at a dose of 0.1 mg/kg; while 8-h urinary Cl- levels were only significantly increased in the group of animals treated with THX at the dose of 0.3 mg/kg. In addition, Ca2+ content was reduced in the 24-h urine of THX-treated NTR and SHR, like that obtained in the HCTZ (10 mg/kg) group. The combination with HCTZ or furosemide, but not with amiloride, significantly enhanced THX-induced diuresis. The diuretic effect with HCTZ plus THX treatment was accompanied by an increase of the urinary Na+, K+, and Cl- excretion. On the other hand, when ...Continue Reading

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Citations

Mar 17, 2020·Journal of Ethnopharmacology·Adarly KrothWania Aparecida Partata
Mar 28, 2021·The Journal of Pharmacy and Pharmacology·Luísa Nathália Bolda MarianoPriscila de Souza
May 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Luísa Nathália Bolda MarianoPriscila de Souza
Aug 4, 2020·European Journal of Pharmacology·Luísa Nathália Bolda MarianoPriscila de Souza

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