PMID: 11929389Apr 4, 2002Paper

13C-aminopyrine breath test to evaluate severity of disease in patients with chronic hepatitis C virus infection

Alimentary Pharmacology & Therapeutics
E G GianniniR Testa

Abstract

There are few data on the use of the 13C-aminopyrine breath test to evaluate the severity of disease in patients with hepatitis C virus-related chronic liver disease, although these patients represent one of the most important problems in clinical hepatology. To compare 13C-aminopyrine breath test results of patients with hepatitis C virus-related chronic hepatitis and Child-Pugh class A cirrhosis with those of normal subjects, and to evaluate different methods of expressing 13C-aminopyrine breath test results. Twenty-four patients with hepatitis C virus-related chronic hepatitis and 17 patients with Child-Pugh class A cirrhosis underwent 13C-aminopyrine breath test. Breath samples were collected every 30 min up to 2 h after 13C-aminopyrine administration. 13C-Aminopyrine breath test results were expressed as a percentage of the administered dose of 13C recovered per hour (% dose/h) and the cumulative percentage of administered dose of 13C recovered over time (% dose cum). Nineteen healthy subjects served as controls. Patients with hepatitis C virus-related chronic hepatitis were divided into subgroups on the basis of histological staging and grading. The 13C-aminopyrine breath test result (% dose/h) at 30 min was significantly...Continue Reading

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Citations

Aug 24, 2006·Digestive Diseases and Sciences·Edoardo G GianniniRoberto Testa
Mar 15, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edoardo G GianniniRoberto Testa
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