PMID: 11340131May 8, 2001Paper

13C breath tests: visions and realities

The Journal of Nutrition
P D Klein

Abstract

Breath tests have been used in research laboratories for over 25 y. Originally, the tests were based on the use of (14)C, rather than on the nonradioactive isotope, (13)C. When (13)C became widely available at a reasonable cost, research groups in the United States and Europe developed methodologies to measure (13)C abundance in samples of CO(2). The tests used a variety of substrates and measured pancreatic function, fat absorption, bacterial overgrowth and P(450) mixed-function oxidase. Thus far, the only test to be approved by the Food and Drug Administration is the (13)C-urea breath test. This manuscript describes the process by which approval is gained, and indicates the steps necessary for other tests to receive Food and Drug Administration approval.

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Citations

Nov 28, 2002·Alimentary Pharmacology & Therapeutics·A ArmuzziA Gasbarrini
Aug 13, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jenifer ChatfieldStanley Konopka
Jul 7, 2007·Scandinavian Journal of Gastroenterology·Tadashi KohnoKunihiko Shibata
Aug 18, 2017·Chemical Society Reviews·Andreas SchwaighoferBernhard Lendl
Jun 26, 2008·Journal of Food Science·F Kong, R P Singh
Apr 9, 2013·Digestive Diseases and Sciences·Martin Stockmann, Johan Friso Lock
Sep 1, 2007·Journal of Breath Research·Anil S Modak
May 8, 2001·The Journal of Nutrition·D Matern, M J Magera

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