13C-Labeled-Starch Breath Test in Congenital Sucrase-isomaltase Deficiency

Journal of Pediatric Gastroenterology and Nutrition
Claudia C Robayo-TorresBuford L Nichols

Abstract

Human starch digestion is a multienzyme process involving 6 different enzymes: salivary and pancreatic α-amylase; sucrase and isomaltase (from sucrose-isomaltase [SI]), and maltase and glucoamylase (from maltase-glucoamylase [MGAM]). Together these enzymes cleave starch to smaller molecules ultimately resulting in the absorbable monosaccharide glucose. Approximately 80% of all mucosal maltase activity is accounted for by SI and the reminder by MGAM. Clinical studies suggest that starch may be poorly digested in those with congenital sucrase-isomaltase deficiency (CSID). Poor starch digestion occurs in individuals with CSID and can be documented using a noninvasive C-breath test (BT). C-Labled starch was used as a test BT substrate in children with CSID. Sucrase deficiency was previously documented in study subjects by both duodenal biopsy enzyme assays and C-sucrose BT. Breath CO2 was quantitated at intervals before and after serial C-substrate loads (glucose followed 75 minutes later by starch). Variations in metabolism were normalized against C-glucose BT (coefficient of glucose absorption). Control subjects consisted of healthy family members and a group of children with functional abdominal pain with biopsy-proven sucrase s...Continue Reading

References

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Jan 1, 1968·Analytical Biochemistry·A Dahlqvist
Mar 1, 1983·The Journal of Pediatrics·C H LifschitzB L Nichols
Jul 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·W R Treem
Apr 29, 2004·The Journal of Nutrition·Erin L SymondsRoss N Butler
Jun 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Roberto Quezada-CalvilloBuford L Nichols
Mar 31, 2009·Journal of Pediatric Gastroenterology and Nutrition·Claudia C Robayo-TorresBuford L Nichols
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Hassan Y NaimKlaus-Peter Zimmer
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Claudia C Robayo-TorresAntone R Opekun
Jul 11, 2013·Journal of Pediatric Gastroenterology and Nutrition·Maricela Diaz-SotomayorBuford L Nichols
Dec 3, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Julien L MarcadierMatthew A Lines
Jun 30, 2016·Annals of Nutrition & Metabolism·Bruno P Chumpitazi, Robert J Shulman
Mar 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsSen-Ichi Oda

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