13C-NMR, MS and metabolic flux balancing in biotechnology research

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13C-NMR, MS and metabolic flux balancing in biotechnology research

Abstract

Citations

Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks.

Analysis of carbon and nitrogen co-metabolism in yeast by ultrahigh-resolution mass spectrometry applying 13C- and 15N-labeled substrates simultaneously

Visual exploration of isotope labeling networks in 3D

Metabolic flux analysis in biotechnology processes

High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13C constraints

High-throughput phenomics: experimental methods for mapping fluxomes

Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites

In vivo analysis of intracellular amino acid labelings by GC/MS

Metabolic isotopomer labeling systems. Part I: global dynamic behavior

Metabolic isotopomer labeling systems. Part II: structural flux identifiability analysis

Metabolic networks of Cucurbita maxima phloem

Strategies for metabolic flux analysis in plants using isotope labelling

Metabolic flux response to phosphoglucose isomerase knock-out in Escherichia coli and impact of overexpression of the soluble transhydrogenase UdhA

Mathematical modelling of metabolism

Can we discover novel pathways using metabolomic analysis?

Mathematical models of metabolic pathways

Production process monitoring by serial mapping of microbial carbon flux distributions using a novel sensor reactor approach: I--Sensor reactor system

Quantifying and assessing the effect of chemical symmetry in metabolic pathways

The challenges of modeling mammalian biocomplexity

(13)C-based metabolic flux analysis.

Deciphering metabolic networks

Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS

Metabolic analysis of wild-type Escherichia coli and a pyruvate dehydrogenase complex (PDHC)-deficient derivative reveals the role of PDHC in the fermentative metabolism of glucose.

The potential of metabolomics tools in bioremediation studies

Planning optimal measurements of isotopomer distributions for estimation of metabolic fluxes

Carbon-fate maps for metabolic reactions

Partial 13C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies

Probing in vivo metabolism by stable isotope labeling of storage lipids and proteins in developing Brassica napus embryos

Quantification of compartmented metabolic fluxes in developing soybean embryos by employing biosynthetically directed fractional (13)C labeling, two-dimensional [(13)C, (1)H] nuclear magnetic resonance, and comprehensive isotopomer balancing

Dissection of central carbon metabolism of hemoglobin-expressing Escherichia coli by 13C nuclear magnetic resonance flux distribution analysis in microaerobic bioprocesses

Metabolic-flux profiling of the yeasts Saccharomyces cerevisiae and Pichia stipitis.

Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris hildenborough using gas chromatography-mass spectrometry and Fourier transform-ion cyclotron resonance mass spectrometry

Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression

Metabolic flux responses to pyruvate kinase knockout in Escherichia coli.

Responses of the central metabolism in Escherichia coli to phosphoglucose isomerase and glucose-6-phosphate dehydrogenase knockouts.

Metabolic engineering in the -omics era: elucidating and modulating regulatory networks

An automated procedure for the extraction of metabolic network information from time series data

Metabolomics in systems biology

The topology of metabolic isotope labeling networks

An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments.

Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum

Fluxome analysis using GC-MS

Priming nonlinear searches for pathway identification

A possibilistic framework for constraint-based metabolic flux analysis.

A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress

A multi-level study of recombinant Pichia pastoris in different oxygen conditions

Fluxomics of the eastern oyster for environmental stress studies

13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy

Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids

Applications of NMR spectroscopy to systems biochemistry

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

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