PMID: 9166030Apr 1, 1997Paper

13Carbon mixed triglyceride breath test and pancreatic enzyme supplementation in cystic fibrosis

Archives of Disease in Childhood
S AmarriL T Weaver

Abstract

Children with cystic fibrosis have variable degrees of exocrine pancreatic insufficiency which, if untreated, is the main cause of fat malabsorption. The impact of pancreatic enzyme supplementation on fat digestion was measured in 41 children with cystic fibrosis, 11 healthy controls, and five children with mucosal diseases by a non-invasive test of intraluminal lipolysis using 13carbon (13C) labelled mixed triglyceride (1,3-distearyl, 2[13C] octanoyl glycerol). The children with cystic fibrosis without pancreatic supplements had a median (range) 13C cumulative percentage dose recovered over six hours (cPDR) of 3.1% (0-31.7), the controls 31.0% (21.8-41.1), and the subjects with mucosal disease 27.8% (19.7-32.5). In 23 subjects with cystic fibrosis the usual dose of pancreatic enzyme supplements increased the cPDR to a median of 23.9% (0-45.6), and twice the usual dose of enteric coated microspheres increased the cPDR to 31.1% (11.1-47.8). There was no significant difference between the median cPDR of normal controls and children with mucosal disease, but there was a highly significant difference between these groups and children with untreated cystic fibrosis. Thirteen children with cystic fibrosis had no 13C recovery in their...Continue Reading

References

Jun 1, 1990·Archives of Disease in Childhood·M S MurphyA Aynsley-Green

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Citations

Oct 24, 1998·Nutrition·L T Weaver
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Sep 11, 2002·Isotopes in Environmental and Health Studies·C SlaterL T Weaver
Jan 28, 2003·Isotopes in Environmental and Health Studies·C A EdwardsL T Weaver
Mar 18, 2006·Isotopes in Environmental and Health Studies·Frans Stellaard, Henk Elzinga
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·P McCleanL T Weaver
Aug 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·K D WutzkeW E Heine
Jun 29, 2001·Journal of Pediatric Gastroenterology and Nutrition·K van Dijk-van AalstG Veereman-Wauters
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·Jaroslaw WalkowiakJohn A Dodge
Oct 15, 1998·Archives of Disease in Childhood·J L MurphyS A Wootton
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·W G MansonL T Weaver
Mar 20, 1999·Gut·L T WeaverG R Swart
Aug 11, 2000·Paediatric Drugs·J M Littlewood, S P Wolfe
Aug 18, 2012·Digestive Diseases and Sciences·P AfolabiA A Jackson
Aug 19, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Caterina AnaniaClaudio Chiesa
Apr 19, 2016·Best Practice & Research. Clinical Gastroenterology·K Nikaki, G L Gupte
Jul 27, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B BradenW F Caspary
Jan 4, 2001·Journal of the American Dietetic Association·D R StapletonP D Sly
Sep 16, 2016·Journal of Pediatric Gastroenterology and Nutrition·Ross N ButlerDouglas J Morrison
Mar 12, 2004·Journal of Gastroenterology and Hepatology·Marc A RitzGeoff Davidson
Nov 30, 2006·Journal of Pediatric Gastroenterology and Nutrition·Christine SlaterLawrence T Weaver
Nov 17, 2005·Pediatric Pulmonology·James M LittlewoodSteven P Conway
Dec 7, 2005·Rapid Communications in Mass Spectrometry : RCM·Christine SlaterLawrence T Weaver
Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·P LionettiA Vierucci
Apr 29, 2015·Journal of Pediatric Gastroenterology and Nutrition·Christopher J TaylorMichael Wilschanski
Aug 26, 1998·Journal of the Royal Society of Medicine·P DurieL Ellis
Oct 28, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Florence MaryClaire Gaudichon
Oct 15, 1998·The British Journal of Nutrition·S AmarriL T Weaver

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