14-3-3ζ is crucial for the conversion of labile short-term object recognition memory into stable long-term memory.

Journal of Neuroscience Research
Irene Navarro-LobatoZafar U Khan

Abstract

The consolidation of new memories into long-lasting memories is multistage process characterized by distinct temporal dynamics. However, our understanding on the initial stage of transformation of labile memory of recent experience into stable memory remains elusive. Here, with the use of rats and mice overexpressing a memory enhancer called regulator of G protein signaling 14 of 414 amino acids (RGS14414 ) as a tool, we show that the expression of RGS14414 in male rats' perirhinal cortex (PRh), which is a brain area crucial for object recognition memory (ORM), enhanced the ORM to the extent that it caused the conversion of labile short-term ORM (ST-ORM) expected to last for 40 min into stable long-term ORM (LT-ORM) traceable after a delay of 24 hr, and that the temporal window of 40 to 60 min after object exposure not only was key for this conversion but also was the time frame when a surge in 14-3-3ζ protein was observed. A knockdown of 14-3-3ζ gene abrogated both the increase in 14-3-3ζ protein and the formation of LT-ORM. Furthermore, this 14-3-3ζ upregulation increased brain-derived growth factor (BDNF) levels in the time frame of 60 min and 24 hr and 14-3-3ζ knockdown decreased the BDNF levels, and a deletion of BDNF gene...Continue Reading

References

Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·C H BaileyE R Kandel
Jun 17, 1998·Molecular Neurobiology·E M Skoulakis, R L Davis
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Apr 3, 2001·Annual Review of Neuroscience·O Steward, E M Schuman
Apr 13, 2001·Current Opinion in Neurobiology·E A Murray, B J Richmond
Jan 15, 2003·The Journal of Biological Chemistry·Ling PanVsevolod V Gurevich
Feb 28, 2003·Molecular Pharmacology·Hongbing Wang, Daniel R Storm
Jun 15, 2004·Current Opinion in Neurobiology·J David Sweatt
May 9, 2006·Seminars in Cancer Biology·Alastair Aitken
Aug 30, 2008·Learning & Memory·Israela BalderasFederico Bermudez-Rattoni
Sep 27, 2008·Neuron·Gary A WaymanThomas R Soderling
Jul 4, 2009·Science·Manuel F López-ArandaZafar U Khan
Jul 7, 2009·Molecular and Cellular Neurosciences·Emily G Waterhouse, Baoji Xu
Feb 4, 2014·Progress in Molecular Biology and Translational Science·Emanuela SantiniEric Klann
Apr 4, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haifa QiaoYi Zhou
Jun 5, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liang WangMu-ming Poo
Jul 3, 2015·Cold Spring Harbor Perspectives in Biology·Craig H BaileyKristen M Harris
Sep 30, 2016·Nature·Stephen C HarwardJames O McNamara
Jun 18, 2017·Cellular and Molecular Neurobiology·Przemysław KowiańskiJanusz Moryś
Jul 22, 2019·International Journal of Molecular Sciences·Xiaolan FanMingyao Yang
Aug 1, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mariam Masmudi-MartínZafar U Khan

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