14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis

Acta Neuropathologica
Yasuhiro KawamotoHerbert Budka

Abstract

14-3-3 proteins are highly conserved eukaryotic proteins that regulate various types of signal transduction pathways through phosphorylation-dependent protein-protein interactions. 14-3-3 mRNAs have been shown to be up-regulated in the injured rat motor neurons and in the spinal cords of patients with amyotrophic lateral sclerosis (ALS). To investigate the role of 14-3-3 proteins in ALS, we performed immunohistochemical studies on 14-3-3 using autopsied spinal cords from patients with sporadic ALS (sALS) and non-ALS subjects without spinal cord involvement. In the anterior horn of both groups, strong 14-3-3 immunoreactivity was observed in the somata and proximal processes of motor neurons. Many spheroids from all of the sALS cases were also immunopositive for 14-3-3. In addition, Lewy body-like hyaline inclusions (LBHIs), which were present in some sALS cases, were intensely immunostained. Our findings suggest that even in the severely affected anterior horn of patients with sALS, remaining motor neurons may contain abundant 14-3-3 proteins, and that 14-3-3 proteins may be partly associated with the pathogenesis of sALS, in particular with the formation of LBHIs.

References

Dec 1, 1992·Trends in Biochemical Sciences·A AitkenJ Soll
Jan 1, 1991·Acta Neuropathologica·T IwatsuboE Miyamoto
Jan 1, 1988·Journal of Neuropathology and Experimental Neurology·D G MunozD J Selkoe
May 1, 1982·Journal of Neurochemistry·P F BostonR J Thompson
May 3, 1996·Neuroscience Letters·R LayfieldR J Mayer
Sep 26, 1996·The New England Journal of Medicine·G HsichM G Harrington
Jun 24, 1998·Brain Research. Molecular Brain Research·K NamikawaH Kiyama
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·P C WongJ D Gitlin
Apr 6, 2000·Neurology·L E Hernández EchebarríaF Fernández
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·H FuS C Masters
Nov 18, 2000·Journal of Neurochemistry·A MalaspinaJ de Belleroche
Mar 15, 2001·European Journal of Biochemistry·P GrantH C Pant
Aug 29, 2001·Neurology·A Martínez-YélamosT Arbizu
Jan 29, 2002·Nature Cell Biology·Hideo FujiwaraTakeshi Iwatsubo
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Yasuhiro KawamotoHerbert Budka
Jun 7, 2002·Current Opinion in Neurobiology·Charles C Fink, Tobias Meyer
Oct 16, 2002·The Journal of Biological Chemistry·Masato HasegawaTakeshi Iwatsubo
Nov 26, 2002·Annals of Neurology·Yasuhiro KawamotoHerbert Budka
Jul 3, 2003·Annals of Neurology·Daniela BergAntje Bornemann
Sep 3, 2003·Nature Reviews. Neuroscience·Daniela BergOlaf Riess
Nov 8, 2003·Acta Neuropathologica·Yasuhiro KawamotoHerbert Budka

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Citations

Sep 8, 2006·Acta Neuropathologica·Yoshitomo ShirakashiMasafumi Ihara
Dec 24, 2013·BioMed Research International·Tadayuki ShimadaKanato Yamagata
Mar 7, 2006·Medical Hypotheses·Kiyotoshi Kaneko, Naomi S Hachiya
Nov 5, 2020·Scientific Reports·Daniela GerovskaMarcos J Araúzo-Bravo
Jul 12, 2013·Journal of Cell Science·Zhe XuYi Zhou

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