14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans

Experimental Gerontology
Caroline AraizSimon Galas

Abstract

Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

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Citations

Jul 21, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Aung Kyaw Swar OoShugo Watabe
Aug 3, 2010·Antioxidants & Redox Signaling·Kelvin YenHeidi A Tissenbaum
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Dec 3, 2014·Developmental and Comparative Immunology·Kim BaertEric Cox
Jul 22, 2019·International Journal of Molecular Sciences·Xiaolan FanMingyao Yang
May 26, 2009·Biochimica Et Biophysica Acta·Robert J Shmookler ReisSrinivas Ayyadevara

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